Proteases in Physiology and Pathology

Editors: Chakraborti, Sajal, Dhalla, Naranjan S. (Eds.)

  • Offers a comprehensive investigation into the regulation of proteases and their pathological consequences
  • Explores the specific inhibitors and molecular probes for proteases to improve therapy for various diseases
  • Serves as valuable resource for those involved in improving protease-targeted therapeutic approaches of life-threatening diseases
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eBook $189.00
price for USA (gross)
  • ISBN 978-981-10-2513-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-981-10-2512-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development.

This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.

About the authors

Dr. Sajal Chakraborti is a senior Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research covers the role of proteases in regulating pulmonary vascular tone under oxidant and calcium signaling phenomena. He has been engaged in teaching and research in biochemistry for the past 40 years.

Dr. Naranjan S Dhalla is a distinguished Professor at the University of Manitoba, Winnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged in multidisciplinary research and education for promoting the scientific basis of cardiology, as well as training of professional manpower for combating heart disease for over 45 years.

Table of contents (28 chapters)

  • Physiological and Pathological Functions of Mitochondrial Proteases

    Bárcena, Clea (et al.)

    Pages 3-25

  • The Role of Matrix Metalloproteinase-2 and Metalloproteinase-9 in Embryonic Neural Crest Cells and Their Derivatives

    Kalev-Altman, Rotem (et al.)

    Pages 27-48

  • The Matrix Metalloproteinase and Tissue Inhibitors of Metalloproteinase Balance in Physiological and Pathological Remodeling of Skeletal Muscles

    Alameddine, Hala S.

    Pages 49-76

  • Role of BMP1/Tolloid like Proteases in Bone Morphogenesis and Tissue Remodeling

    Chakraborty, Sibani (et al.)

    Pages 77-88

  • Role of Proteases in the Regulation of N-Myristoyltransferase

    Kumar, Sujeet (et al.)

    Pages 89-99

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-981-10-2513-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-981-10-2512-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Proteases in Physiology and Pathology
Editors
  • Sajal Chakraborti
  • Naranjan S. Dhalla
Copyright
2017
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-2513-6
DOI
10.1007/978-981-10-2513-6
Hardcover ISBN
978-981-10-2512-9
Edition Number
1
Number of Pages
XV, 619
Number of Illustrations and Tables
19 b/w illustrations, 78 illustrations in colour
Topics