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  • © 2015

Stress Response Pathways in Cancer

From Molecular Targets to Novel Therapeutics

  • The book covers very recent research that promises to revolutionize cancer-directed chemotherapeutic interventions
  • The book provides a unique translational coverage between molecular cancer biology and cancer-directed therapeutic development
  • The book provides state-of-the-art coverage written by recognized experts from five continents
  • Includes supplementary material: sn.pub/extras

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eBook USD 129.00
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Softcover Book USD 169.99
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Hardcover Book USD 179.99
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  • Durable hardcover edition
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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xii
  2. Cell Cycle Checkpoint and DNA Damage Response Defects as Anticancer Targets: From Molecular Mechanisms to Therapeutic Opportunities

    • Loredana Spoerri, Zay Yar Oo, Jill E. Larsen, Nikolas K. Haass, Brian Gabrielli, Sandra Pavey
    Pages 29-49
  3. Sirtuins as a Double-Edged Sword in Cancer: From Molecular Mechanisms to Therapeutic Opportunities

    • Núria Sima, Laia Bosch-Presegué, Alejandro Vaquero
    Pages 75-106
  4. MicroRNA Regulated Stress Responses in Cancer

    • Haoran Li, Shaan Gupta, Burton B. Yang
    Pages 107-126
  5. Senescence in Oncogenesis: From Molecular Mechanisms to Therapeutic Opportunities

    • Sandra Muñoz-Galvan, Amancio Carnero
    Pages 127-155
  6. Pro-senescence Therapy for Cancer: Time for the Clinic

    • Madhuri Kalathur, Diletta Di Mitri, Andrea Alimonti
    Pages 157-182
  7. The Hsp70 Family of Heat Shock Proteins in Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities

    • Anna Budina-Kolomets, Subhasree Basu, Lili Belcastro, Maureen E. Murphy
    Pages 203-224
  8. The Ubiquitin-Proteasome System (UPS) as a Cancer Drug Target: Emerging Mechanisms and Therapeutics

    • Lydia Mata-Cantero, Sofía Lobato-Gil, Fabienne Aillet, Valérie Lang, Manuel S. Rodriguez
    Pages 225-264
  9. At the Crossroads Between Mitochondrial Metabolite Transport and Apoptosis: VDAC1 as an Emerging Cancer Drug Target

    • Varda Shoshan-Barmatz, Anna Shteinfer, Danya Ben-Hail, Tasleem Arif, Dario Mizrachi
    Pages 345-373
  10. Inflammatory Dysregulation and Cancer: From Molecular Mechanisms to Therapeutic Opportunities

    • Colin W. Steele, Nigel B. Jamieson, C. Ross Carter
    Pages 375-395
  11. Cell-Nonautonomous ER Stress-Mediated Dysregulation of Immunity by Cancer Cells

    • Jeffrey J. Rodvold, Navin R. Mahadevan, Maurizio Zanetti
    Pages 397-429
  12. Back Matter

    Pages 431-446

About this book

It is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near future. Coauthored by recognized leaders in cancer research from five continents, this novel book provides a comprehensive perspective on cell stress response pathways and therapeutic opportunities. Focusing on the role of genotoxic, proteotoxic, oxidative, metabolic, and inflammatory stress in tumorigenesis, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in cancer and therapeutic development.

Editors and Affiliations

  • Dept. of Pharmacology and Toxicology, Univ. of Arizona, College of Pharm. & The Univ. of Arizona Cancer Ctr., Tucson, USA

    Georg T. Wondrak

Bibliographic Information

  • Book Title: Stress Response Pathways in Cancer

  • Book Subtitle: From Molecular Targets to Novel Therapeutics

  • Editors: Georg T. Wondrak

  • DOI: https://doi.org/10.1007/978-94-017-9421-3

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2015

  • Hardcover ISBN: 978-94-017-9420-6Published: 21 November 2014

  • Softcover ISBN: 978-94-024-0385-5Published: 10 September 2016

  • eBook ISBN: 978-94-017-9421-3Published: 07 November 2014

  • Edition Number: 1

  • Number of Pages: XII, 446

  • Number of Illustrations: 4 b/w illustrations, 52 illustrations in colour

  • Topics: Cancer Research, Cell Biology, Oncology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access