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Tumor Dormancy, Quiescence, and Senescence, Vol. 3

Aging, Cancer, and Noncancer Pathologies

  • Book
  • © 2014

Overview

Editors:
  1. M.A. Hayat

    1. Department of Biological Sciences, Kean University, Union, USA

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  • Discusses the effects of senescence and dormancy in breast cancer, ovarian cancer and leukemia, as well as in cardiovascular diseases
  • Advances the body of knowledge of cancer cell regression, including possible use of pro senescence therapy as an alternative to surgery, chemotherapy or radiation therapy
  • Includes the contributions of some 26 experts representing seven different countries
  • Includes supplementary material: sn.pub/extras

Part of the book series: Tumor Dormancy and Cellular Quiescence and Senescence (DOQU, volume 3)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xxvi
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  3. Role in Breast Cancer

    1. Front Matter

      Pages 49-49
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    2. Various Factors Contributing to Tumor Dormancy: Therapeutic Implications in Breast Cancer

      • Natalia Krawczyk, Malgorzata Banys, Hans Neubauer, Tanja Fehm
      Pages 51-57

    3. Progression of Hormone-Dependent Mammary Tumors After Dormancy: Role of Wnt Pathway

      • Albana Gattelli, Martín C. Abba, Julián Naipauer, M. Victoria Goddio, Johanna M. Tocci, Nancy E. Hynes et al.
      Pages 59-75

  4. Role in Ovarian Cancer

    1. Front Matter

      Pages 77-77
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    2. Chemoresistance, Dormancy and Recurrence in Platinum Drug Therapy of Ovarian Cancers

      • Tamara A. Kalir, D. Stave Kohtz
      Pages 79-97

    3. The Role of Angiogenesis, Growth Arrest and Autophagy in Human Ovarian Cancer Xenograft Models for Tumor Dormancy

      • Margie N. Sutton, Zhen Lu, Robert C. Bast Jr.
      Pages 99-109

  5. Role in Leukemia

    1. Front Matter

      Pages 111-111
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    2. Regulation of the Promyelocytic Leukemia Protein and Its Role in Premature Senescence

      • Alan W. Lau, Adriana E. Tron, Wenyi Wei
      Pages 113-122

  6. Role in Cardiovascular Disease

    1. Front Matter

      Pages 123-123
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    2. Cardiac Senescence and Autophagy

      • Ken Shinmura
      Pages 125-137

  7. Back Matter

    Pages 139-144
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Keywords

About this book

This third volume in the series Tumor Dormancy, Quiescence, and Senescence discusses the role of tumor dormancy and senescence in a number of diseases, including breast cancer, ovarian cancer and leukemia. The contents are organized under five subheadings: General Applications, Role in Breast Cancer, Role in Ovarian Cancer, Role in Leukemia and Role in Cardiovascular Disease. The first section includes basic information on the definition of dormancy, how cells become senescent and what they do, along with an appraisal of the current state of research on dormancy. Section Two explores dormancy in breast cancer, including the progression of hormone-dependent mammary tumors after dormancy. Section Three details the resistance of Type II ovarian tumors, in which the resistant tumor cell population persists after chemotherapy in a state of dormancy, with recurrent tumors arising upon transformation of such dormant cells back to malignant growth. This section explains how lineage, histological subtypes and grade influence the differential response of ovarian cancer resistance to platinum drugs. The fourth section explores leukemia, discussing regulation of the promyelocytic leukemia protein and its role in premature senescence. The final section explores the role of senescence and autophagy in age-related cardiovascular diseases and the observation that autophagy seems to retard cardiac senescence. Like the two preceding volumes in the series, Volume 3 stands out for its comprehensive approach, its roster of some 26 expert contributors representing seven different countries and its up-to-date review of leading-edge technology and methods.

Editors and Affiliations

  • Department of Biological Sciences, Kean University, Union, USA

    M.A. Hayat

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