Tumor Dormancy and Cellular Quiescence and Senescence

Tumor Dormancy, Quiescence, and Senescence, Vol. 3

Aging, Cancer, and Noncancer Pathologies

Editors: Hayat, M.A. (Ed.)

  • Discusses the effects of senescence and dormancy in breast cancer, ovarian cancer and leukemia, as well as in cardiovascular diseases
  • Advances the body of knowledge of cancer cell regression, including possible use of pro senescence therapy as an alternative to surgery, chemotherapy or radiation therapy
  • Includes the contributions of some 26 experts representing seven different countries
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eBook $159.00
price for USA (gross)
  • ISBN 978-94-017-9325-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-94-017-9324-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-94-024-0807-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This third volume in the series Tumor Dormancy, Quiescence, and Senescence discusses the role of tumor dormancy and senescence in a number of diseases, including breast cancer, ovarian cancer and leukemia. The contents are organized under five subheadings: General Applications, Role in Breast Cancer, Role in Ovarian Cancer, Role in Leukemia and Role in Cardiovascular Disease. The first section includes basic information on the definition of dormancy, how cells become senescent and what they do, along with an appraisal of the current state of research on dormancy. Section Two explores dormancy in breast cancer, including the progression of hormone-dependent mammary tumors after dormancy. Section Three details the resistance of Type II ovarian tumors, in which the resistant tumor cell population persists after chemotherapy in a state of dormancy, with recurrent tumors arising upon transformation of such dormant cells back to malignant growth. This section explains how lineage, histological subtypes and grade influence the differential response of ovarian cancer resistance to platinum drugs. The fourth section explores leukemia, discussing regulation of the promyelocytic leukemia protein and its role in premature senescence. The final section explores the role of senescence and autophagy in age-related cardiovascular diseases and the observation that autophagy seems to retard cardiac senescence. Like the two preceding volumes in the series, Volume 3 stands out for its comprehensive approach, its roster of some 26 expert contributors representing seven different countries and its up-to-date review of leading-edge technology and methods.

Table of contents (10 chapters)

  • Active, Dormant, or on the Path to Elimination: What Does a Senescent Cell Do?

    Ben-Porath, Ittai

    Pages 3-12

  • Hypoxia and Tumor Dormancy: Can the Two Tango?

    Sertil, Aparna R.

    Pages 13-24

  • Progeroid Syndromes: Role of Accelerated Fibroblast Senescence and p38 Activation

    Davis, Terence

    Pages 25-39

  • Induction of Cancer Cell Senescence: Role of Caffeic Acid 3,4-Dihydroxy-Phenethyl Ester

    Luo, Jian (et al.)

    Pages 41-48

  • Various Factors Contributing to Tumor Dormancy: Therapeutic Implications in Breast Cancer

    Krawczyk, Natalia (et al.)

    Pages 51-57

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-94-017-9325-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-94-017-9324-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • ISBN 978-94-024-0807-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Tumor Dormancy, Quiescence, and Senescence, Vol. 3
Book Subtitle
Aging, Cancer, and Noncancer Pathologies
Editors
  • M.A. Hayat
Series Title
Tumor Dormancy and Cellular Quiescence and Senescence
Series Volume
3
Copyright
2014
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-017-9325-4
DOI
10.1007/978-94-017-9325-4
Hardcover ISBN
978-94-017-9324-7
Softcover ISBN
978-94-024-0807-2
Edition Number
1
Number of Pages
XXVI, 144
Number of Illustrations and Tables
19 illustrations in colour
Topics