Advances in Experimental Medicine and Biology

I Domain Integrins

Editors: Gullberg, Donald (Ed.)

  • Features the latest information on I Domain Integrins
  • Features the latest information on these transmembrane receptors
  • Will be a valuable source of information for academic, as well as biotech and pharma researchers
see more benefits

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-94-017-9153-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-94-017-9152-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 3, 2016
  • ISBN 978-94-024-0290-2
  • Free shipping for individuals worldwide
About this book

The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version.

I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition.

Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book.

In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling.

New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.

Table of contents (11 chapters)

  • Evolution of Integrin I Domains

    Johnson, Mark S. (et al.)

    Pages 1-19

  • Integrin α1β1

    Gardner, Humphrey

    Pages 21-39

  • α2β1 Integrin

    Madamanchi, Aasakiran (et al.)

    Pages 41-60

  • Integrin α10β1: A Collagen Receptor Critical in Skeletal Development

    Lundgren-Åkerlund, Evy (et al.)

    Pages 61-71

  • Integrin α11β1: A Major Collagen Receptor on Fibroblastic Cells

    Zeltz, Cédric (et al.)

    Pages 73-83

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-94-017-9153-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-94-017-9152-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 3, 2016
  • ISBN 978-94-024-0290-2
  • Free shipping for individuals worldwide
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
I Domain Integrins
Editors
  • Donald Gullberg
Series Title
Advances in Experimental Medicine and Biology
Series Volume
819
Copyright
2014
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-017-9153-3
DOI
10.1007/978-94-017-9153-3
Hardcover ISBN
978-94-017-9152-6
Softcover ISBN
978-94-024-0290-2
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIV, 179
Number of Illustrations and Tables
18 b/w illustrations, 32 illustrations in colour
Topics