Translation and Its Regulation in Cancer Biology and Medicine

Editors: Parsyan, Armen (Ed.)

  • Assembles and analyzes a wealth of information from decades of research on the role of dysregulated protein synthesis, translation, in cancer biology
  • Explores the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology
  • Discusses various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery in cancer
  • Considers existing and novel treatments of cancer, based on targeting of the translation machinery
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eBook $189.00
price for USA (gross)
  • ISBN 978-94-017-9078-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-94-017-9077-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-94-024-0351-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development.

Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology.

The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia.

The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.

Table of contents (34 chapters)

  • Introduction

    Parsyan, Armen

    Pages 1-3

  • Mechanism of Translation in Eukaryotes

    Villa, Nancy (et al.)

    Pages 7-37

  • Diverse Mechanisms of Translation Regulation and Their Role in Cancer

    Villa, Nancy (et al.)

    Pages 39-71

  • eIF4E and Its Binding Proteins

    Robichaud, Nathaniel (et al.)

    Pages 73-113

  • RNA Helicases and Their Cofactors

    Shahbazian, David (et al.)

    Pages 115-134

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-94-017-9078-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-94-017-9077-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $239.00
price for USA
  • ISBN 978-94-024-0351-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Translation and Its Regulation in Cancer Biology and Medicine
Editors
  • Armen Parsyan
Copyright
2014
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-017-9078-9
DOI
10.1007/978-94-017-9078-9
Hardcover ISBN
978-94-017-9077-2
Softcover ISBN
978-94-024-0351-0
Edition Number
1
Number of Pages
XXXIV, 697
Number of Illustrations and Tables
8 b/w illustrations, 44 illustrations in colour
Topics