A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems

Editors: Kulkarni, Vishwesh, Stan, Guy-Bart, Raman, Karthik (Eds.)

  • New rigorous methods to obtain better predictive models of biological networks
  • New results on the limits of performance in biological networks
  • Includes novel applications of in vitro synthetic biology in nanotechnology
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eBook $149.00
price for USA (gross)
  • ISBN 978-94-017-9047-5
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  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-94-017-9046-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 10, 2016
  • ISBN 978-94-024-0337-4
  • Free shipping for individuals worldwide
About this book

The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems.  More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. 

Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. 

Volume II contains chapters contributed by leading researchers in the field of systems and synthetic biology that concern modeling physiological processes and bottom-up constructions of scalable biological systems.  The modeling problems include characterisation and synthesis of memory, understanding how homoeostasis is maintained in the face of shocks and relatively gradual perturbations, understanding the functioning and robustness of biological clocks such as those at the core of circadian rhythms, and understanding how the cell cycles can be regulated, among others. Some of the bottom-up construction problems investigated in Volume II are as follows: How should biomacromolecules, platforms, and scalable architectures be chosen and synthesised in order to build programmable de novo biological systems? What are the types of constrained optimisation problems encountered in this process and how can these be solved efficiently? 

As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.

Table of contents (12 chapters)

  • Network Biomarker Construction for Molecular Investigation and Diagnosis of Lung Cancer via Microarray Data

    Wang, Yu-Chao (et al.)

    Pages 3-29

  • The Impact of Next-Generation Sequencing Technology on Bacterial Genomics

    Lal, Avantika (et al.)

    Pages 31-58

  • Sensitivity Analysis of Circadian Entrainment in the Space of Phase Response Curves

    Sacré, Pierre (et al.)

    Pages 59-81

  • Modelling and Analysis of Feedback Control Mechanisms Underlying Osmoregulation in Yeast

    Montefusco, Francesco (et al.)

    Pages 83-116

  • Analysis of Synchronizing Biochemical Networks via Incremental Dissipativity

    Hamadeh, Abdullah (et al.)

    Pages 117-139

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-94-017-9047-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-94-017-9046-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 10, 2016
  • ISBN 978-94-024-0337-4
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems
Editors
  • Vishwesh Kulkarni
  • Guy-Bart Stan
  • Karthik Raman
Copyright
2014
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-017-9047-5
DOI
10.1007/978-94-017-9047-5
Hardcover ISBN
978-94-017-9046-8
Softcover ISBN
978-94-024-0337-4
Edition Number
1
Number of Pages
XVIII, 298
Number of Illustrations and Tables
30 b/w illustrations, 77 illustrations in colour
Topics