A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations

Editors: Kulkarni, Vishwesh, Stan, Guy-Bart, Raman, Karthik (Eds.)

  • New rigorous methods to obtain better predictive models of biological networks
  • New results on the limits of performance in biological networks
  • Includes novel applications of in vitro synthetic biology in nanotechnology
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eBook $129.00
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  • ISBN 978-94-017-9041-3
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Hardcover $199.99
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  • ISBN 978-94-017-9040-6
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  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 4, 2016
  • ISBN 978-94-024-0787-7
  • Free shipping for individuals worldwide
About this book

The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems.  More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. 

Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. 

Volume I provides a panoramic view that illustrates the potential of such mathematical methods in systems and synthetic biology.  Recent advances in systems and synthetic biology have clearly demonstrated the benefits of a rigorous and systematic approach rooted in the principles of systems and control theory - not only does it lead to exciting insights and discoveries but it also reduces the inordinately lengthy trial-and-error process of wet-lab experimentation, thereby facilitating significant savings in human and financial resources.  In Volume I, some of the leading researchers in the field of systems and synthetic biology demonstrate how systems and control theoretic concepts and techniques can be useful, or should evolve to be useful, in order to understand how biological systems function. 

As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.

Table of contents (12 chapters)

  • On the Mathematics of the Law of Mass Action

    Adleman, Leonard (et al.)

    Pages 3-46

  • Structural Analysis of Biological Networks

    Blanchini, Franco (et al.)

    Pages 47-71

  • Guaranteeing Spatial Uniformity in Reaction-Diffusion Systems Using Weighted $$L^2$$ Norm Contractions

    Aminzare, Zahra (et al.)

    Pages 73-101

  • Robust Tunable Transcriptional Oscillators Using Dynamic Inversion

    Kulkarni, Vishwesh V. (et al.)

    Pages 103-119

  • Towards the Modular Decomposition of the Metabolic Network

    Goelzer, Anne (et al.)

    Pages 121-152

Buy this book

eBook $129.00
price for USA (gross)
  • ISBN 978-94-017-9041-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA
  • ISBN 978-94-017-9040-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 4, 2016
  • ISBN 978-94-024-0787-7
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations
Editors
  • Vishwesh Kulkarni
  • Guy-Bart Stan
  • Karthik Raman
Copyright
2014
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-017-9041-3
DOI
10.1007/978-94-017-9041-3
Hardcover ISBN
978-94-017-9040-6
Softcover ISBN
978-94-024-0787-7
Edition Number
1
Number of Pages
XVIII, 332
Number of Illustrations and Tables
43 b/w illustrations, 41 illustrations in colour
Topics