Angiogenesis and Anti-Angiogenesis in Hematological Malignancies

Authors: Ribatti, Domenico

  • Describes the critical role Angiogenesis plays in tumor progression and metastasis
  • Information on Anti-angiogenesis, one of most promising approaches to the treatment of cancer and metastasis
  • Deals with several anti-angiogenic molecules currently used alone or in combination in the treatment of haematological malignancies
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eBook $109.00
price for USA (gross)
  • ISBN 978-94-017-8035-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-94-017-8034-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 3, 2016
  • ISBN 978-94-024-0305-3
  • Free shipping for individuals worldwide
About this book

It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular niche”, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.

Reviews

From the reviews:

“This book will appeal mainly to researchers in the field of angiogenesis/antiangiogenesis, and students. … This is a comprehensive book on an important area of cancer research that is often overshadowed by literature on solid tumors. It will be most helpful for researchers looking for information on the subject, but it also enlightens practitioners on the mechanisms of action of some common treatments for hematological malignancies.” (Leslie Popplewell, Doody’s Book Reviews, June, 2014)

Table of contents (6 chapters)

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-94-017-8035-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-94-017-8034-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 3, 2016
  • ISBN 978-94-024-0305-3
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Angiogenesis and Anti-Angiogenesis in Hematological Malignancies
Authors
Copyright
2014
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-017-8035-3
DOI
10.1007/978-94-017-8035-3
Hardcover ISBN
978-94-017-8034-6
Softcover ISBN
978-94-024-0305-3
Edition Number
1
Number of Pages
XI, 114
Number of Illustrations and Tables
14 b/w illustrations, 30 illustrations in colour
Topics