Dendritic Cells: Biophysics, Tumor Microenvironment and Chinese Traditional Medicine

1. Front Matter

   Pages i-vii

   PDF

2. Introduction

   • Zhu Zeng, Xiaofeng Xu, Dan Chen

   Pages 1-4

3. The Measurement Protocols for Cell’s Biophysical Characteristics

   • Zhu Zeng, Xiaofeng Xu, Dan Chen

   Pages 5-10

4. Biophysical Characteristics of DCs at Different Differentiation Stages

   • Zhu Zeng, Xiaofeng Xu, Dan Chen

   Pages 11-23

5. Biophysical Characteristics of DCs in Tumor Microenvironment

   • Zhu Zeng, Xiaofeng Xu, Dan Chen

   Pages 25-53

6. Effects of Traditional Chinese Medicine on DCs Under Tumor Microenvironment

   • Zhu Zeng, Xiaofeng Xu, Dan Chen

   Pages 55-63

7. Future Perspectives

   • Zhu Zeng, Xiaofeng Xu, Dan Chen

   Pages 65-66

In this book, the authors discuss the biophysical characteristics of Dendritic cells (DCs) at various differentiation stages and in tumor microenvironments in detail. A type of Chinese traditional herb, which can improve the biophysical and microrheological properties of DCs, is also introduced. DCs are potent and specialized antigen-presenting cells that play a crucial role in initiating and amplifying both the innate and adaptive immune responses. The biophysical and microrheological characteristics of DCs are important for their motility and normal immune function. In tumor microenvironments, the motility and immune functions of DCs are impaired, but the mechanisms are largely unknown. This book offers researchers a comprehensive and deep insight into the biophysical characteristics of DCs and may also help to improve the efficiency of anti-tumor therapy based on DCs.   

 

• biophysics
• dendritic cells
• immune escape mechanisms of tumor cells
• microrheology
• motility

• School of Biology and Engineering, Guizhou Medical University, Guiyang, China

  Zhu Zeng

• Laboratory Medicine, Beijing Tongren Hospital Capital Medical University, Beijing, China

  Xiaofeng Xu

• Department of Pharmacology, Tianjin Medical University, School of Basic Medical Sciences, Tianjin, China

  Dan Chen

Zhu Zeng is a professor of the Department of Biotechnology, and the vice president of the School of Basic Medical Sciences, Guiyang Medical College. He was awarded as the distinguished young science and technology scholars of Guizhou Province in 2011. Since 2000, his main research interests focused on biophysical characteristics of dendritic cells.  Xiaofeng Xu is a doctor in the department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University. Her research interests focused on biophysical characteristics of dendritic cells. 
Dan Chen is a lecturer of the Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University. Her main research interests focused on the effects of traditional Chinese medicine on tumor biological behaviors.

Policies and ethics