DNA Replication - Damage from Environmental Carcinogens

1. Front Matter

   Pages i-xi

   PDF

2. DNA Replication

   • Huidong Zhang

   Pages 1-4

3. Disturbances of the DNA Replication System

   • Huidong Zhang

   Pages 5-13

4. Fate of DNA Replisome upon Encountering DNA Damage

   • Huidong Zhang

   Pages 15-19

5. External Causes for DNA Damage

   • Huidong Zhang

   Pages 21-26

6. Effect of Environmental Carcinogens on Cellular Physiology

   • Huidong Zhang

   Pages 27-34

7. Protocols for Studies of Bypass of DNA Damage by DNA Polymerase

   • Huidong Zhang

   Pages 35-43

This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health.

• Cell activities
• DNA damage
• DNA replisome
• Environmental carcinogens
• Experiment protocols

“It is focused on how environmental carcinogens affect DNA replication because it is well-known that correct DNA replication is the first crucial factor for the integrity of genetic informa­tion. … The book is an interesting and enriching contribution which can help to understand the impact of environmental carcinogens on living organism.” (Darina Slamenova, Neoplasma, Vol. 63 (2), 2016)

• Institute of Toxicology, the Third Military Medical University Preventive Medical College, Chongqing, China

  Huidong Zhang

Dr. Huidong Zhang is a professor and assistant director of the Institute of Toxicology, Preventive Medical College, Third Military Medical University in China, and the winner of China’s “Thousand Youth Talents Plan.” His research focuses on DNA damage and replication, and he has published more than 20 original research articles in international peer-reviewed journals such as the PNAS, JBC and Cell Cycle.​

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