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Subcellular Biochemistry

Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)

Editors: Fonta, Caroline, Negyessy, Laszlo (Eds.)

  • Offers a wealth of new information on alkaline phosphatase TNAP functions in the nervous system
  • Opens up new insights on the regulation of neural functions
  • A valuable resource for both researchers and clinicians
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eBook $269.00
price for USA
  • ISBN 978-94-017-7197-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.00
price for USA
  • ISBN 978-94-017-7196-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer's disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs.

Table of contents (18 chapters)

  • Clinical Forms and Animal Models of Hypophosphatasia

    Salles, Jean Pierre

    Pages 3-24

  • Molecular Genetics of Hypophosphatasia and Phenotype-Genotype Correlations

    Mornet, Etienne

    Pages 25-43

  • Genetically Modified Mice for Studying TNAP Function

    Narisawa, Sonoko

    Pages 45-57

  • Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis

    Zimmermann, Herbert (et al.)

    Pages 61-84

  • Rediscovering TNAP in the Brain: A Major Role in Regulating the Function and Development of the Cerebral Cortex

    Fonta, Caroline (et al.)

    Pages 85-106

Buy this book

eBook $269.00
price for USA
  • ISBN 978-94-017-7197-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.00
price for USA
  • ISBN 978-94-017-7196-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)
Editors
  • Caroline Fonta
  • Laszlo Negyessy
Series Title
Subcellular Biochemistry
Series Volume
76
Copyright
2015
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-017-7197-9
DOI
10.1007/978-94-017-7197-9
Hardcover ISBN
978-94-017-7196-2
Series ISSN
0306-0225
Edition Number
1
Number of Pages
XXII, 395
Number of Illustrations and Tables
21 b/w illustrations, 37 illustrations in colour
Topics