Transplantation and Changing Management of Organ Failure

1. Front Matter

   Pages i-ix

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2. Past and future alternatives and strategies

   1. Front Matter

      Pages 1-1

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   2. Trends in the epidemiology of end-stage renal disease over the last decade

      • Paul Landais

      Pages 3-28

   3. Answers to liver graft shortage: hepatocyte transplantation and bioartificial liver

      • Yvon Calmus

      Pages 29-37

   4. Enzymatic and biochemical substitutes to organ transplantation in inborn errors of metabolism

      • Pierre Cochat, Nathalie Guffon, Bruno Ranchin, Alain Fouilhoux

      Pages 39-45

   5. Tolerance induction

      • Kathryn J. Wood

      Pages 47-55

   6. Xenotransplantation: immunological advances

      • Gilles Blancho

      Pages 57-58

3. Liver replacement therapy

   1. Front Matter

      Pages 59-59

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   2. Living donor in liver transplantation as novel graft source

      • Olivier Boillot

      Pages 61-66

   3. Ex-situ liver support

      • Isabelle Méchet

      Pages 67-73

4. Renal replacement therapy

   1. Front Matter

      Pages 75-75

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   2. Preventing end-stage renal disease: fact or fiction?

      • Bertram L. Kasiske

      Pages 77-95

   3. Transplantation and short daily haemodialysis

      • J. Traeger, R. Galland, E. Delawari, W. Arkouche

      Pages 97-105

   4. Comparison of survival probabilities between renal transplant recipients and patients undergoing regular dialysis: a single centre prospective study

      • G. P. Segoloni, G. Tognarelli, V. Alfieri, F. Fop, G. Piccoli

      Pages 107-114

   5. Transplantation versus dialysis in aged and type II diabetic patients

      • C. Pouteil-Noble, E. Villar, D. Babici, R. Ecochard

      Pages 115-128

5. Pancreas replacement therapy

   1. Front Matter

      Pages 129-129

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   2. External and implantable insulin pumps: current place in the treatment of diabetes

      • J.-L. Selam

      Pages 131-138

   3. Pancreas and islet transplantation in the treatment of type I diabetes

      • X. Martin, P. Petruzzo, N. Lefrancois, L. Badet, J. M. Dubernard

      Pages 139-143

   4. Perspectives in early detection and management of IDDM

      • C. Thivolet

      Pages 145-149

6. Heart and lung replacement therapy

   1. Front Matter

      Pages 151-151

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This book, the proceedings of the 32nd International Conference on Transplantation and Clinical Immunology, held in Lyon, France, on May 25-26, 2000, addresses novel issues in terms of changing indications for transplantation in the management of organ failure, whether humans will remain the only source for organ procurement, prospects for engineering in organ replacement, and whether transplantation will remain the most appropriate approach to organ failure. Some promising treatments are approached, such as enzymic and biochemical replacement, gene therapy, tolerance induction, stem cell transplantation, and xenotransplantation. In addition to the constant improvement in conservative management of organ failure in general, ongoing research in selected fields is reported in the proceedings, such as liver transplantation vs artificial liver, novel dialysis strategies vs evolving immunosuppression in kidney transplantation, islets transplantation and external implantable insulin pumps vs pancreas transplantation in diabetic patients, circulatory assistance and intramyocardial myoblast injection vs heart transplantation. Pivotal experience in selected emerging transplantations is included, that is, small bowel, limb, skin and neuronal transplantation. Such fascinating perspectives raise medical, economical, and ethical problems which are discussed in this book.

• diseases
• gene therapy
• immunosuppression
• kidney
• liver transplantation
• organ
• organ transplantation
• stem cell transplantation
• transplantation

Policies and ethics