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Developments in Nuclear Medicine

Clinical Use of Antibodies

Tumours, infection, infarction, rejection and in the diagnosis of AIDS

Editors: Baum, R.P., Cox, P.H., Hör, G., Buraggi, G.L. (Eds.)

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Softcover $129.00
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About this book

It was at Frankfurt/Mainin 1899 that Paul Ehrlich first expounded his famous "site-chain theory" -which described the basic immunological principal of antibody-antigen interactio- on the occasion of the opening of the Institute for Experimental Therapeutics (which was later named after him). Nearly 100 years have passed since, and in retrospect it can be said that the "Ehrlich Era" (first steps in immunology "Magic Bullet" concept) and the "Behring Era" (detection of antibodies and serum therapy) formed the essential basis in the development of immunology. Niels K. Jerne, the former director of the Paul Ehrlich Institute in Frankfurt/Main received, together with Georges Kohler and Cesar Milstein, the Nobel Prize in Medicine 1984. These late successors of Ehrlich and Behring first described the hybridoma technology (in 1975) which enabled one of the most important and revolutionary technological innovations in the field of immunology -the production of monoclonal antibodies. It happens that, the time of the publication of this book, just a decade has passed since the first use of radiolabelled monoclonal antibodies in man (by the Lausanne Group). Over these 10 years a tremendous progress has taken place in the field of immunoscintigraphy:A large panel of highly specific monoclonal antibodies against tumour-associated antigens as well as normal cell compounds have been developed. Enormous progress has been made in the field of radiolabelling -from iodine-131 to technetium-99mor even positron-emittingradionuclides, e. g. iodine-124.

Reviews

'To conclude, this is a summary of research findings in Nuclear Medicine of predominant interest to Nuclear Medicine Physicians particularly those interested in "magic bullets", especially biological ones.' Australian Cancer Society 16:3 1992

Table of contents (14 chapters)

  • Advances in Cancer Imaging and Therapy with Radiolabelled Antibodies

    Goldenberg, D. M.

    Pages 1-13

  • Evaluation of the Diagnostic Utility of Immunoscintigraphy in Oncology

    Buraggi, G. L.

    Pages 15-30

  • The Quality Control and Clinical Testing of Radiolabelled Antibodies

    Cox, Peter H. (et al.)

    Pages 31-35

  • Clinical Utility of Radiolabelled Monoclonal Antibodies in the Management of Gastrointestinal Cancer

    Chatal, J. F. (et al.)

    Pages 37-44

  • Use of 123-I Radiolabelled F(AB’)2 Fragments of Anti-CEA Monoclonal Antibody for the Detection of Primary and Metastatic Gastrointestinal Carcinomas

    Bamias, A. (et al.)

    Pages 45-53

Buy this book

eBook $99.00
price for USA (gross)
  • ISBN 978-94-011-3516-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $129.00
price for USA
  • ISBN 978-94-010-5555-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Clinical Use of Antibodies
Book Subtitle
Tumours, infection, infarction, rejection and in the diagnosis of AIDS
Editors
  • Richard P Baum
  • P.H. Cox
  • Gustav Hör
  • Gian Luigi Buraggi
Series Title
Developments in Nuclear Medicine
Series Volume
19
Copyright
1991
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-011-3516-0
DOI
10.1007/978-94-011-3516-0
Softcover ISBN
978-94-010-5555-0
Edition Number
1
Number of Pages
X, 185
Topics