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The Biological Effects of Glutamic Acid and Its Derivatives

  • Book
  • © 1981

Overview

Editors:
  1. V. A. Najjar
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Part of the book series: Developments in Molecular and Cellular Biochemistry (DMCB, volume 1)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-4
    Download chapter PDF

  2. Hippocampal glutamate receptors

    • Michel Baudry, Gary Lynch
    Pages 5-18

  3. Enzymatic synthesis and function of folylpolyglutamates

    • John J. McGuire, Joseph R. Bertino
    Pages 19-48

  4. δ-Aminolaevulinic acid and amino acid neurotransmitters

    • M. J. W. Brennan, R. C. Cantrill
    Pages 49-58

  5. γ-Glutamylamine cyclotransferase

    • Mary Lynn Fink, J. E. Folk
    Pages 59-67

  6. GABA and the enteric nervous system

    • K. R. Jessen
    Pages 69-76

  7. Post-translational carboxylation of preprothrombin

    • B. Connor Johnson
    Pages 77-121

  8. Glutamate and aspartate agonists structurally related to ibotenic acid

    • Tage Honoré, Povl Krogsgaard-Larsen, Jan J. Hansen, Jørn Lauridsen
    Pages 123-128

  9. GABA agonists

    • Povl Krogsgaard-Larsen, Erik Falch
    Pages 129-146

  10. Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture

    • Robert L. Macdonald, Anne B. Young
    Pages 147-162

  11. Molecular characteristics of glutamate receptors in the mammalian brain

    • E. K. Michaelis, M. L. Michaelis, H. H. Chang, R. D. Grubbs, D. R. Kuonen
    Pages 163-179

  12. Pyroglutamic acid

    • George N. Abraham, David N. Podell
    Pages 181-190

  13. Gamma-carboxyglutamic acid

    • John P. Burnier, Marianne Borowski, Barbara C. Furie, Bruce Furie
    Pages 191-207

  14. Folylpoly-γ-glutamate synthesis by bacteria and mammalian cells

    • David J. Cichowicz, Siang K. Foo, Barry Shane
    Pages 209-228

  15. Immunocytochemical and autoradiographic localization of GABA system in the vertebrate retina

    • Jang-Yen Wu, Christopher Brandon, Y. Y. Thomas Su, Dominic M. K. Lam
    Pages 229-238

  16. L-glutamate transport in renal plasma membrane vesicles

    • Bertram Sacktor
    Pages 239-251

  17. Glutamate as a precursor of GABA in rat brain and peripheral tissues

    • Helen L. White
    Pages 253-259

  18. The GABA postsynaptic membrane receptor-ionophore complex

    • Richard W. Olsen
    Pages 261-279

  19. The stimulation of ion fluxes in brain slices by glutamate and other excitatory amino acids

    • Vivian I. Teichberg, Ora Goldberg, Alberto Luini
    Pages 281-295

  20. Alterations of central GABAergic activity in neurologic and psychiatric disorders: evaluation through measurements of GABA and GAD activity in cerebrospinal fluid

    • Theodore A. Hare
    Pages 297-304
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Keywords

About this book

the GABA increase takes place and (2) the area of the brain that may mediate the anticonvulsant Investigation of the physiology, biochemistry, activity. Three compounds that increase brain pharmacology and anatomy of GAB A and GABA­ GABA by distinct mechanisms were used in these containing neural systems, continues to reveal the studies: di-n-propylacetate (DPA, sodium val­ rich complexities associated with this neuroactive proate, Depakene(R)), amino-oxyacetic acid amino acid (see recent symposia 1,2,3). Advances (AOAA) and y-vinyl GABA (GVG). in the pharmacology of GABA-mimetic agents In the next sections, the metabolism of GABA have resulted in the development of compounds and a brief historical account of the relationship that can selectively activate GABA receptors (4,5, between GABA and anticonvulsant activity are 6, 7), inhibit the synthetic and degradative enzymes outlined followed by a discussion ofthe biochemical for GABA (8, 9) or affect the neuronal and glial and pharmacological effects of the three drugs. In uptake processes for GABA (10, 11). This has particular, the literature pertaining to the suppres­ already had a significant impact on our under­ sion of seizures and the correlation between anti­ standing of the role of GABA in convulsions and a convulsant action and increases in brain G ABA will range of other CNS functions including feeding be examined. (12), cardiovascular control (13), motor activity (14) and release of pituitary hormones (15). Before 1.

Bibliographic Information

  • Book Title: The Biological Effects of Glutamic Acid and Its Derivatives

  • Editors: V. A. Najjar

  • Series Title: Developments in Molecular and Cellular Biochemistry

  • DOI: https://doi.org/10.1007/978-94-009-8027-3

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff/Dr W. Junk Publishers, The Hague 1981

  • Softcover ISBN: 978-94-009-8029-7Published: 09 October 2011

  • eBook ISBN: 978-94-009-8027-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 384

  • Topics: Medical Biochemistry

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