Influence of Tumor Development on the Host

1. Front Matter

   Pages i-x

   PDF

2. Aspects of the primary tumor

   1. Stroma, Generally a Non-Neoplastic Structure of the Tumor

      • H. E. Kaiser

      Pages 1-8

   2. Malignant Transformation

      • H. E. Kaiser

      Pages 9-17

   3. Metabolic Changes in Malignancy

      • Freddie A. Hoffman

      Pages 18-27

   4. Ion Deregulation, Cell Injury and Tumor Promotion

      • Benjamin F. Trump, Irene K. Berezesky, Kookmin M. Kim

      Pages 28-34

   5. Multiple Primary Neoplasms: Role of Autopsy. Selected Sites, with Emphasis on Japan

      • Shaw Watanabe

      Pages 35-39

   6. Multiple Primary Neoplasms

      • H. E. Kaiser

      Pages 40-57

3. Shared aspects of primary and secondary tumors

   1. Mechanisms of Cancer Invasion and Metastases

      • Lance A. Liotta

      Pages 58-71

   2. Extracellular Matrix and Its Enzymatic Degradation in Tumor Invasion

      • Karl Tryggvason

      Pages 72-83

   3. Cell Surfaces and Secondary Tumor Formation

      • Garth L. Nicolson

      Pages 84-96

   4. DNA Transfection, Genetic Instability, and Metastasis

      • Ann F. Chambers

      Pages 97-102

   5. The Contribution of DNA Methylation to the Generation of Tumor Cell Heterogeneity, Tumor Progression and Metastasis

      • Robert G. Liteplo, Robert S. Kerbel, Philip Frost

      Pages 103-111

   6. Neoplastic Progression by Somatic Cell Fusion

      • Patrick De Baetselier

      Pages 112-120

   7. Cell Junctional Alterations in Cancer

      • Bendicht U. Pauli, Ronald S. Weinstein

      Pages 121-132

   8. Cytogenetic Studies in Neoplasia (Human and Animal): Implications Prognosis, and Treatment

      • Jacqueline Whang-Peng, Turid Knutsen

      Pages 133-175

   9. Cancer Cachexia

      • S. D. Morrison

      Pages 176-213

   10. Paraneoplastic Syndromes

       • Robert A. Nagourney, Paul V. Woolley

       Pages 214-227

4. Back Matter

   Pages 228-240

   PDF

Recent experimental evidence has made it increasingly clear In particular, this volume reviews the discrete steps involved that the properties of invasive, malignant cells during tumor in metastatic invasion: the interaction of invasive tumor cells development substantially impact on the host. This is under­ with extracellular matrices, the basement membrane, attach­ scored by a variety of biochemical properties of tumor cells ment to extracellular matrices, local proteolytic degradation during their differentiation and metastatic dissemination. of matrices, and the locomotion of invasive tumor cells These properties can be analyzed at different stages of tumor through such areas of localized degradation. The critical growth and progression and this volume explores the role of the cell surface in secondary tumor formation is characteristics of primary tumors as well as the shared reviewed as are important advances in the molecular biology characteristics of both primary and secondary tumors. of metastasis initiation and maintenance. Recent advances The primary tumor comes into existence following in the role of DNA methylation in the generation of tumor preneoplastic biochemical and cellular events that ultimate­ cell heterogeneity and tumor progression are also critically ly result in malignant transformation. Various aspects of summarized. Chapters in this volume also review molecular metabolism, predetermined by nutritional status, often play aspects of metastatic progression, and the use of the tech­ a basic role. Obesity, for example, is cancer-promoting. Cell nologies of DNA transfection and somatic cell fusion in the surface carbohydrates, cytoskeletal proteins, glycoproteins, exploration of molecular aspects of metastatic progression.

• DNA
• Tumor
• cancer
• cell
• metastasis
• tumor progression

`... the present volume offers a wealth of detailed information of great interest to pathologists to be used in basic research as well as in his clinical activities.'

• Department of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, USA

  Lance A. Liotta

Policies and ethics