Tumor Dormancy and Cellular Quiescence and Senescence

Tumor Dormancy, Quiescence, and Senescence, Volume 2

Aging, Cancer, and Noncancer Pathologies

Editors: Hayat, M.A. (Ed.)

  • Role of Dormancy in various cancer types is explained
  • Role of Senescence in the aging process is also included
  • Mechanisms underlying premature cellular senescence is detailed
  • The discussion in chapters is reinforced by color figures and Tables
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eBook $159.00
price for USA (gross)
  • ISBN 978-94-007-7726-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-94-007-7725-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 3, 2016
  • ISBN 978-94-024-0766-2
  • Free shipping for individuals worldwide
About this book

In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries.

Table of contents (28 chapters)

  • Asymmetric Dimethylarginine Accelerates Cellular Senescence

    Scalera, Fotunato (et al.)

    Pages 3-16

  • Membrane-Derived Extracellular Vesicles from Endothelial Progenitor Cells Activate Angiogenesis

    Cantaluppi, Vincenzo (et al.)

    Pages 17-25

  • Induction of P21-Dependent Senescence: Role of NAE Inhibitor MLN4924

    Pan, Yongfu (et al.)

    Pages 27-32

  • Regulation of the Novel Senescence Pathway by SKP2 E3 Ligase

    Wang, Guocan (et al.)

    Pages 33-43

  • Oncogene-Induced Senescence: Role of Mitochondrial Dysfunction

    Moiseeva, Olga (et al.)

    Pages 45-52

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-94-007-7726-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-94-007-7725-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 3, 2016
  • ISBN 978-94-024-0766-2
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Tumor Dormancy, Quiescence, and Senescence, Volume 2
Book Subtitle
Aging, Cancer, and Noncancer Pathologies
Editors
  • M.A. Hayat
Series Title
Tumor Dormancy and Cellular Quiescence and Senescence
Series Volume
2
Copyright
2014
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-007-7726-2
DOI
10.1007/978-94-007-7726-2
Hardcover ISBN
978-94-007-7725-5
Softcover ISBN
978-94-024-0766-2
Edition Number
1
Number of Pages
XXVII, 320
Number of Illustrations and Tables
16 b/w illustrations, 33 illustrations in colour
Topics