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Heat Shock Proteins of Malaria

  • Book
  • © 2014

Overview

Editors:
  1. Addmore Shonhai

    1. Dept. of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa

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  2. Gregory L. Blatch

    1. College of Health and Biomedicine, Victoria University, Melbourne, Australia

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    You can also search for this editor in PubMed   Google Scholar

  • This is a novel area of malaria research that is very topical
  • All of the chapters are written by leaders or experts in the field
  • The chapters on drug discovery will appeal to the biotechnology industry
  • Includes supplementary material: sn.pub/extras

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Importance of Molecular Chaperones in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparum

    • Jude Przyborski
    Pages 1-3

  3. General Structural and Functional Features of Molecular Chaperones

    • Adrienne L. Edkins, Aileen Boshoff
    Pages 5-45

  4. The Role of Hsp70s in the Development and Pathogenicity of Plasmodium Species

    • Addmore Shonhai
    Pages 47-69

  5. Role of the Hsp40 Family of Proteins in the Survival and Pathogenesis of the Malaria Parasite

    • Eva-Rachele Pesce, Alexander G. Maier, Gregory L. Blatch
    Pages 71-85

  6. Role of Hsp90 in Plasmodium falciparum Malaria

    • Dea Shahinas, Dylan R. Pillai
    Pages 87-97

  7. The Role of Parasite Heat Shock Proteins in Protein Trafficking and Host Cell Remodeling

    • Paul R. Gilson, Sarah C. Charnaud, Brendan S. Crabb
    Pages 99-117

  8. Role of Heat Shock Proteins in Immune Modulation in Malaria

    • Evelyn Böttger, Gabriele Multhoff
    Pages 119-132

  9. Establishment of Plasmodium falciparum Extracellular Compartments in its Host Erythrocyte

    • Alassane Mbengue, Laurence Berry, Catherine Braun-Breton
    Pages 133-159

  10. Chaperones and Proteases of Plasmodium falciparum

    • Kaiyin Liu, Walid A. Houry
    Pages 161-187

  11. Heat Shock Proteins as Targets for Novel Anti-Malarial Drugs

    • Manish Grover, Shweta Chaubey, Utpal Tatu
    Pages 189-205

  12. Heat Shock Proteins of Malaria: What Do We Not Know, and What Should the Future Focus Be?

    • Addmore Shonhai, Gregory L. Blatch
    Pages 207-211

  13. Back Matter

    Pages 213-223
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Keywords

About this book

This book describes the role of heat shock proteins in the life cycle of malaria parasites. The work includes a general introduction on the structural and functional features of heat shock proteins. The main focus is on the role of heat shock protein families from Plasmodium falciparum, their role in protein folding and in the development of malaria pathology. The functions of individual families of heat shock proteins from plasmodium species and their cooperation in functional networks is described. Subcellular and extracellular organelles such as the apicoplast and the Maurer’s Clefts which are associated with plasmodium species, are discussed in detail. The role of heat shock proteins in the development and function of these organelles structures are highlighted. Although conceding that heat shock proteins may not be ideal antimalarial drug targets, prospects of targeting heat shock proteins in antimalarial drug discovery either directly and/or in combination therapies are explored.

Editors and Affiliations

  • Dept. of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa

    Addmore Shonhai

  • College of Health and Biomedicine, Victoria University, Melbourne, Australia

    Gregory L. Blatch

Bibliographic Information

  • Book Title: Heat Shock Proteins of Malaria

  • Editors: Addmore Shonhai, Gregory L. Blatch

  • DOI: https://doi.org/10.1007/978-94-007-7438-4

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2014

  • Softcover ISBN: 978-94-024-0259-9Published: 23 August 2016

  • eBook ISBN: 978-94-007-7438-4Published: 20 September 2013

  • Edition Number: 1

  • Number of Pages: VIII, 223

  • Number of Illustrations: 2 b/w illustrations, 33 illustrations in colour

  • Topics: Biomedicine general, Parasitology, Protein Science, Infectious Diseases

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