Advances in Experimental Medicine and Biology

G Protein-Coupled Receptors - Modeling and Simulation

Editors: Filizola, Marta (Ed.)

  • This book is unique in its sort
  • The GPCR field is fast evolving, and computational techniques such as those described in this book, are becoming more and more utilized
  • Includes state-of-the-art views on modeling and simulation by recognized experts with an established reputation in the development and/or application of computational methods to GPCRs
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eBook $149.00
price for USA (gross)
  • ISBN 978-94-007-7423-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-94-007-7422-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-94-024-0258-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors. Luckily, there has been a steady increase of high-resolution crystal structures of these receptors since 2007, and this information, integrated with dynamic inferences from computational and experimental methods, holds great potential for the discovery of new, improved drugs. This book, which provides, for the first time, state-of-the-art views on modeling and simulation of GPCRs, is divided into 4 parts. In the first part, the impact of currently available GPCR crystal structures on structural modeling is discussed extensively as are critical insights from simulations in the second part of the book. The third part reports recent progress in rational ligand discovery and mathematical modeling, whereas the fourth part provides an overview of bioinformatics tools and resources that are available for GPCRs.

Table of contents (10 chapters)

  • The GPCR Crystallography Boom: Providing an Invaluable Source of Structural Information and Expanding the Scope of Homology Modeling

    Costanzi, Stefano (et al.)

    Pages 3-13

  • Modeling of G Protein-Coupled Receptors Using Crystal Structures: From Monomers to Signaling Complexes

    Gonzalez, Angel (et al.)

    Pages 15-33

  • Structure and Dynamics of G-Protein Coupled Receptors

    Vaidehi, Nagarajan (et al.)

    Pages 37-54

  • How the Dynamic Properties and Functional Mechanisms of GPCRs Are Modulated by Their Coupling to the Membrane Environment

    Mondal, Sayan (et al.)

    Pages 55-74

  • Coarse-Grained Molecular Dynamics Provides Insight into the Interactions of Lipids and Cholesterol with Rhodopsin

    Horn, Joshua N. (et al.)

    Pages 75-94

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-94-007-7423-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-94-007-7422-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $189.00
price for USA
  • ISBN 978-94-024-0258-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
G Protein-Coupled Receptors - Modeling and Simulation
Editors
  • Marta Filizola
Series Title
Advances in Experimental Medicine and Biology
Series Volume
796
Copyright
2014
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-007-7423-0
DOI
10.1007/978-94-007-7423-0
Hardcover ISBN
978-94-007-7422-3
Softcover ISBN
978-94-024-0258-2
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VIII, 228
Number of Illustrations and Tables
14 b/w illustrations, 45 illustrations in colour
Topics