Subcellular Biochemistry

Proteins and Proteomics of Leishmania and Trypanosoma

Editors: Santos, A., Branquinha, M., d’Avila-Levy, C., Kneipp, L., Sodré, C. (Eds.)

  • The book presents an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera
  • The book contains an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells
  • The chapters contain several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures
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Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-94-007-7305-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-94-007-7304-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 3, 2016
  • ISBN 978-94-024-0749-5
  • Free shipping for individuals worldwide
About this book

This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids’ genera are etiological agents of leishmaniasis, Chagas’ disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteomics of Leishmania and Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.

Reviews

From the book reviews:

“This is an updated review of the current understanding of the molecular, cellular biology, and biochemistry aspects, including protein expression and functions of the two protozoan parasitic genera, Leishmania and Trypanosoma. … this is a good book for both undergraduate and postgraduate students as well as researchers in the field. … This is a well-organized book outlining the current understanding of the biology and biochemistry of two important parasitic agents.” (Vaibhav Tiwari, Doody’s Book Reviews, January, 2015)

Table of contents (15 chapters)

  • Biology of Human Pathogenic Trypanosomatids: Epidemiology, Lifecycle and Ultrastructure

    Rodrigues, Juliany Cola Fernandes (et al.)

    Pages 1-42

  • Selection of Molecular Targets for Drug Development Against Trypanosomatids

    Smirlis, Despina (et al.)

    Pages 43-76

  • A2 and Other Visceralizing Proteins of Leishmania: Role in Pathogenesis and Application for Vaccine Development

    Fernandes, Ana Paula (et al.)

    Pages 77-101

  • Arginase in Leishmania

    Silva, Maria Fernanda Laranjeira (et al.)

    Pages 103-117

  • The Heat Shock Proteins of Trypanosoma cruzi

    Ürményi, Turán P. (et al.)

    Pages 119-135

Buy this book

eBook $159.00
price for USA (gross)
  • ISBN 978-94-007-7305-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $209.00
price for USA
  • ISBN 978-94-007-7304-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $209.00
price for USA
  • Customers within the U.S. and Canada please contact Customer Service at 1-800-777-4643, Latin America please contact us at +1-212-460-1500 (Weekdays 8:30am – 5:30pm ET) to place your order.
  • Due: November 3, 2016
  • ISBN 978-94-024-0749-5
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Proteins and Proteomics of Leishmania and Trypanosoma
Editors
  • Andre Santos
  • Marta Branquinha
  • Claudia d’Avila-Levy
  • Lucimar Kneipp
  • Cátia Sodré
Series Title
Subcellular Biochemistry
Series Volume
74
Copyright
2014
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-007-7305-9
DOI
10.1007/978-94-007-7305-9
Hardcover ISBN
978-94-007-7304-2
Softcover ISBN
978-94-024-0749-5
Series ISSN
0306-0225
Edition Number
1
Number of Pages
X, 381
Number of Illustrations and Tables
18 b/w illustrations, 37 illustrations in colour
Topics