Pediatric Cancer

Pediatric Cancer, Volume 4

Diagnosis, Therapy, and Prognosis

Editors: Hayat, M.A. (Ed.)

  • Offers comprehensive, up-to-date coverage of a broad range of pediatric tumors
  • Discusses Neuroblastoma, Medulloblastoma, Leukemia, Lymphoma, Rhabdoid, Sarcoma and Miscellaneous Tumors
  • Features the work of 91 experts - oncologists, neurosurgeons, physicians, research scientists and pathologists - representing 13 countries
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eBook $219.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-94-007-6591-7
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  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
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Hardcover $279.00
price for USA
valid through November 5, 2017
  • ISBN 978-94-007-6590-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA
valid through November 5, 2017
  • ISBN 978-94-024-0726-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This entry in the series Pediatric Cancer offers comprehensive information on a variety of cancers, concentrating on brain tumors, the most common solid tumors and the leading cause of cancer-related mortality in children. The contents are organized in seven sections: Neuroblastoma, Medulloblastoma, Leukemia, Lymphoma, Rhabdoid, Sarcoma and Miscellaneous Tumors.

Coverage includes pediatric medulloblastoma, and treatments including craniospinal radiation followed by adjuvant chemotherapy. The contributors explain diagnosis and chemotherapy of children with acute lymphoblastic leukemia, and diagnosis of bone marrow involvement in pediatric lymphoma patients. Ewing’s sarcoma, a highly malignant connective tissue neoplasm formed by the proliferation of mesenchymal cells, receives extensive coverage, including targeting of molecular pathways and chemotherapy and surgical treatment. The roles of apoptotic genes, MYCN gene, MDM2, and SNP309, P13K inhibitors, alternative splicing and microRNAs, activated leukocyte cell adhesion molecule and inhibition by alu-like RNA in neuroblastoma are discussed in detail.

The book explores the molecular genetics, diagnosis, prognosis and therapy of the atypical teratoid/rhabdoid tumor (AT/RT). Among the most common malignant neoplasms in children, AT/RT exhibits similarities with other CNS tumors, which can lead to misclassification, as pointed out in the book. The contributors discuss diagnosis of AT/RT type using imaging technology, and describe new strategies, including intensive multimodal therapy and high dose chemotherapy with autologous stem cell transplantation that have shown improved outcomes. Coverage of therapies includes total resection followed by aggressive chemotherapy and radiation.

Discussion includes diagnosis and treatment of other pediatric tumors including adrenocortical tumors, supratentorial primitive neuroectodermal tumors, giant midline tumors, gastrointestinal stromal tumors, ependymomas and intramedullary cavernoma.

Pediatric Cancer: Diagnosis, Therapy and Prognosis, Volume 4 includes contributions by ninety-one contributors - oncologists, neurosurgeons, physicians, research scientists and pathologists - representing thirteen countries.

The editor, M.A. Hayat, is a Distinguished Professor in the Department of Biological Sciences at Kean University, Union, New Jersey, USA.

Table of contents (33 chapters)

  • Pediatric Neuroblastoma: Use of Hypermethylation of Apoptotic Genes as a Prognostic Factor

    Yañez, Yania (et al.)

    Pages 3-10

  • MYCN Nonamplified Neuroblastoma: Detection of Tumor-Derived Cell-Free DNA in Serum for Predicting Prognosis of Neuroblastoma

    Yagyu, Shigeki (et al.)

    Pages 11-17

  • Neuroblastoma: Role of MDM2 and SNP309 as Markers

    Cattelani, Sara (et al.)

    Pages 19-25

  • Role of PI3K Inhibitors in Sensitizing Neuroblastoma Cells to Apoptosis

    Fulda, Simone

    Pages 27-35

  • Regulation of Neuroblastoma Cell Differentiation by Retinoic Acid: Role of Alternative Splicing and micro-RNAs

    Meseguer, Salvador (et al.)

    Pages 37-47

Buy this book

eBook $219.00
price for USA (gross)
valid through November 5, 2017
  • ISBN 978-94-007-6591-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
valid through November 5, 2017
  • ISBN 978-94-007-6590-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA
valid through November 5, 2017
  • ISBN 978-94-024-0726-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pediatric Cancer, Volume 4
Book Subtitle
Diagnosis, Therapy, and Prognosis
Editors
  • M.A. Hayat
Series Title
Pediatric Cancer
Series Volume
4
Copyright
2013
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-007-6591-7
DOI
10.1007/978-94-007-6591-7
Hardcover ISBN
978-94-007-6590-0
Softcover ISBN
978-94-024-0726-6
Series ISSN
2211-7997
Edition Number
1
Number of Pages
XXXVI, 346
Number of Illustrations and Tables
23 b/w illustrations, 32 illustrations in colour
Topics