The Tumor Immunoenvironment

1. Front Matter

   Pages i-xvi

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2. Role of the Immunological Environment in Cancer Initiation, Development and Progression

   • Anatoli Malyguine, Viktor Umansky, Michael R. Shurin

   Pages 1-12

3. Tumor Microenvironment and Immunoenvironment

   1. Front Matter

      Pages 13-13

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   2. The Metastatic Microenvironment

      • Shelly Maman, Isaac P. Witz

      Pages 15-38

   3. Tumor Infiltration by Immune Cells: Pathologic Evaluation and a Clinical Significance

      • Dmitriy W. Gutkin

      Pages 39-82

   4. Immunologic Interpretation of Cancer Biology: Impact on Clinical Outcome

      • Maria Libera Ascierto, Francesco M. Marincola, Ena Wang

      Pages 83-104

4. Developmental Characteristics of the Tumor Immunoenvironment

   1. Front Matter

      Pages 105-105

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   2. Development of Antitumor Cellular Immunity

      • M. J. P. Welters, S. H. van der Burg

      Pages 107-133

   3. The Versatile World of Inflammatory Chemokines in Cancer

      • Tal Leibovich-Rivkin, Yaeli Lebel-Haziv, Shalom Lerrer, Polina Weitzenfeld, Adit Ben-Baruch

      Pages 135-175

   4. Inflammation, Tumor Progression, and Immune Suppression

      • Suzanne Ostrand-Rosenberg, Pratima Sinha

      Pages 177-196

   5. Pleiotropic and Differential Functions of IL-1α and IL-1β Shape the Tumor Microenvironment and Affect the Outcome of Malignancies

      • Ron N. Apte, Elena Voronov

      Pages 197-222

   6. Impact of Obesity and Aging on the Tumor Immuno-Environment

      • Annie Mirsoian, Gail D. Sckisel, Anthony E. Zamora, William J. Murphy

      Pages 223-250

5. Tumor Escape from Immune Recognition

   1. Front Matter

      Pages 251-251

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   2. MHC Class I Antigens and the Tumor Microenvironment

      • Natalia Aptsiauri, Teresa Cabrera, Angel Garcia-Lora, Francisco Ruiz-Cabello, Federico Garrido

      Pages 253-286

   3. Tumor-Produced Immune Regulating Factors

      • Mads Hald Andersen, Jürgen C. Becker, Per thor Straten

      Pages 287-306

   4. Roles of Signaling Pathways in Cancer Cells and Immune Cells in Generation of Immunosuppressive Tumor-Associated Microenvironments

      • Yutaka Kawakami, Tomonori Yaguchi, Hidetoshi Sumimoto, Chie Kudo-Saito, Nobuo Tsukamoto, Tomoko Iwata-Kajihara et al.

      Pages 307-323

   5. T Cell Mulfunction in the Tumor Environment

      • Eitan Yefenof

      Pages 325-338

   6. Signaling of Tumor-Induced Immunosuppression of Dendritic Cells

      • Yong Lu, Jing Yang, Qing Yi

      Pages 339-360

   7. Tumor Microenvironment may Shape the Function and Phenotype of NK Cells Through the Induction of Split Anergy and Generation of Regulatory NK Cells

      • Anahid Jewett, Han-Ching Tseng

      Pages 361-381

6. Immune Regulators in the Tumor Immunoenvironment

   1. Front Matter

      Pages 383-383

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Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.

• Cancer immunomonitoring
• Cancer immunotherapy
• Cancer-mediated immunomodulation
• Tumor immunobiology
• Tumor microenvironment

• Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, USA

  Michael R. Shurin

• , Clinical Cooperation Unit Dermato-Oncolo, German Cancer Research Center, Heidelberg, Germany

  Viktor Umansky

• , SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, USA

  Anatoli Malyguine

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