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  • Book
  • © 2013

Tight Junctions in Cancer Metastasis

  • First Tight Junction & Cancer Metastasis book
  • Information on a wide range of cancer types
  • Information of tight junction proteins
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Metastasis - Biology and Treatment (CMBT)

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eBook USD 129.00
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Softcover Book USD 169.99
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Hardcover Book USD 169.99
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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
  2. The Molecular Aspects of Tight Junctions

    • Elaine A. McSherry, Mark B. Owens, Ann M. Hopkins
    Pages 1-27
  3. The Distribution of Tight Junctions and Junctional Proteins in the Human Body

    • Anna-Maria Tokes, Zsuzsa Schaff, Attila Marcell Szasz, Janina Kulka
    Pages 29-64
  4. Methods to Study Tight Junctions

    • María Isabel Larre, Catalina Flores-Maldonado, Marcelino Cereijido
    Pages 65-80
  5. Tight Junctions, Junctional Adhesion Molecules (JAMs), and the Blood Brain Barrier

    • Klaus Ebnet, Benjamin F. Brinkmann, Daniel Kummer, Steve Misselwitz, Swetha S. D. Peddibhotla, Hüseyin Tuncay
    Pages 119-129
  6. Tight Junctions in Human Urinary Bladder Cancer

    • Tracey A. Martin, Mark Haynes, Ninaard Answare, Gareth Brown, Wen G. Jiang
    Pages 131-148
  7. Tight Junctions in Colorectal Cancer

    • Frédéric Hollande, Marina Papin
    Pages 149-167
  8. Regulation of Tight Junctions for Therapeutic Advantages

    • Lorenza González-Mariscal, Mónica Díaz-Coránguez, Miguel Quirós
    Pages 197-246
  9. Claudin-5 and Cancer Metastasis

    • Cláudia Malheiros Coutinho-Camillo, Silvia Vanessa Lourenço, Fernando Augusto Soares
    Pages 263-274
  10. The ROCK Signalling Pathway and Tight Junctions

    • Jane Lane, Tracey A. Martin, Wen G. Jiang
    Pages 291-301
  11. Back Matter

    Pages 303-313

About this book

There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.

Editors and Affiliations

  • Cardiff University, Institute of Cancer & Genetics, Cardiff, United Kingdom

    Tracey A. Martin, Wen G. Jiang

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access