Proteins of the Nucleolus

1. Front Matter

   Pages i-vi

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Proteins of the Nucleolus: An Introduction

      • Danton H. O’Day, Andrew Catalano

      Pages 3-15

3. The Nucleolus and Nucleolar Proteins

   1. Front Matter

      Pages 17-17

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   2. Functional Consequences of Nuclear and Nucleolar Architecture

      • Eva Bártová, Lenka Stixová

      Pages 19-38

   3. rDNA and Nucleologenesis in Drosophila

      • Patrick DiMario, Allison James, Himanshu Raje

      Pages 39-78

   4. The Nucleolus of Dictyostelium and Other Lower Eukaryotes

      • Andrew Catalano, Danton H. O’Day

      Pages 79-94

   5. Human rDNA Genes: Identification of Four Fractions, Their Functions and Nucleolar Location

      • Nataliya A. Lyapunova, Nataliya N. Veiko, Lev N. Porokhovnik

      Pages 95-118

   6. Chromatin Organization and the Mammalian Nucleolus

      • Attila Németh, Gernot Längst

      Pages 119-148

   7. Chaperones and Multitasking Proteins in the Nucleolus

      • Mohamed Kodiha, Ursula Stochaj

      Pages 149-172

4. Nucleolar Protein Translocation

   1. Front Matter

      Pages 173-173

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   2. Nucleolar Localization/Retention Signals

      • Eugene V. Sheval, Yana R. Musinova

      Pages 175-196

   3. Nucleolar Transport of Putative GTPase GNL1 and Related Proteins

      • S. Mahalingam, M. R. K. Subba Rao, Neelima Boddapati, T. Indu Jose, Debduti Datta

      Pages 197-207

   4. Nucleolar Protein Anchoring and Translocation

      • Krzysztof Staroń, Agnieszka Girstun

      Pages 209-247

5. Nucleolar Proteins and Disease

   1. Front Matter

      Pages 249-249

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   2. The Nucleolus as a Stress Response Organelle

      • Mikael S. Lindström, Leena Latonen

      Pages 251-273

   3. The Nucleolar Aspect of Breast Cancer

      • Judy Yan, Damu Tang

      Pages 275-304

   4. Cysteine Proteinase Inhibitors in the Nucleus and Nucleolus in Activated Macrophages

      • Nataša Kopitar-Jerala

      Pages 305-321

   5. Nucleolar Proteins and Cancer: The Roles of Aurora A-Interacting Nucleolar Proteins in Mitosis and Cancer

      • Jyoti Iyer, Saili Moghe, Manabu Furukawa, Ming-Ying Tsai

      Pages 323-342

   6. Nucleolar Transplantation and Human Embryogenesis

      • Helena Fulka, Alena Langerova, Stanislava Martinkova, Josef Fulka Jr.

      Pages 343-357

This book contains 14 original review chapters each yielding new, exciting and intriguing data about the emerging understanding of nucleolar structure and function in normal, stressed and diseased cells. The goal of this work is to provide special insight into the nucleolus of the past, present and future, as well its regulation, translocation, and biomedical function. A multitude of topics are introduced and discussed in detail, including nucleologenesis, nucleolar architecture, nucleolar targeting, retention, anchoring, translocation, and the relationship between the nucleolus and cancer. This book also brings together work from several different species, from human to Drosophila to Dictyostelium and other eukaryotic microbes. The final chapter summarizes some of the issues brought up in the various chapters with a view to future research. This book supports the continued emergence of the nucleolus as a dynamic intranuclear region that oversees a vast diversity of events.

• Disease
• Nucleolus
• Ribosomal DNA
• Signalling
• Targetting
• Biological Microscopy

• , Biology, University of Toronto at Mississauga, Mississauga, Canada

  Danton H O'Day, Andrew Catalano

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