Current Topics in Microbiology and Immunology

Phosphoinositides and Disease

Editors: Falasca, Marco (Ed.)

  • A comprehensive overview of the current state of research and where the field of research is progressing to
  • A useful tool for understanding how inositol signaling is used to target complex human diseases
  • Increase our understanding of the role of inositol signaling in protein regulation
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eBook $169.00
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  • ISBN 978-94-007-5025-8
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Hardcover $219.00
price for USA
  • ISBN 978-94-007-5024-1
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Softcover $219.00
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  • ISBN 978-94-007-9426-9
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About this book

Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.

Table of contents (12 chapters)

  • An Introduction to Phosphoinositides

    Maffucci, Tania

    Pages 1-42

  • Phosphoinositides and Cardiovascular Diseases

    Ghigo, Alessandra (et al.)

    Pages 43-60

  • Phosphoinositides in Insulin Action and Diabetes

    Bridges, Dave (et al.)

    Pages 61-85

  • Phosphoinositides in Neuroexocytosis and Neuronal Diseases

    Wen, Peter J. (et al.)

    Pages 87-98

  • Effects of Phosphoinositides and Their Derivatives on Membrane Morphology and Function

    Larijani, Banafshé (et al.)

    Pages 99-110

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-94-007-5025-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-94-007-5024-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-94-007-9426-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Phosphoinositides and Disease
Editors
  • Marco Falasca
Series Title
Current Topics in Microbiology and Immunology
Series Volume
362
Copyright
2012
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-007-5025-8
DOI
10.1007/978-94-007-5025-8
Hardcover ISBN
978-94-007-5024-1
Softcover ISBN
978-94-007-9426-9
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VI, 318
Topics