Subcellular Biochemistry

GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

Editors: Dupré, Denis J., Hébert, Terence E., Jockers, Ralf (Eds.)

  • This is the first book addressing specifically the assembly of G protein coupled receptors signaling complexes
  • Several colors images
  • Compilations of manuscripts made from experts in the field
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eBook $169.00
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  • ISBN 978-94-007-4765-4
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Hardcover $219.00
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  • ISBN 978-94-007-4764-7
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  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
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  • ISBN 978-94-017-8099-5
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About this book

Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.

Table of contents (14 chapters)

  • ER-Bound Steps in the Biosynthesis of G Protein-Coupled Receptors

    Nanoff, Christian (et al.)

    Pages 1-21

  • Role of Chaperones in G Protein Coupled Receptor Signaling Complex Assembly

    Dupré, Denis J. (et al.)

    Pages 23-42

  • GPCR Oligomerization: Contribution to Receptor Biogenesis

    Craenenbroeck, Kathleen

    Pages 43-65

  • The Functional Size of GPCRs – Monomers, Dimers or Tetramers?

    Pétrin, Darlaine (et al.)

    Pages 67-81

  • Regulation of Post-Golgi Traffic of G Protein-Coupled Receptors

    Wu, Guangyu

    Pages 83-95

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-94-007-4765-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-94-007-4764-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-94-017-8099-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity
Editors
  • Denis J. Dupré
  • Terence E. Hébert
  • Ralf Jockers
Series Title
Subcellular Biochemistry
Series Volume
63
Copyright
2012
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-007-4765-4
DOI
10.1007/978-94-007-4765-4
Hardcover ISBN
978-94-007-4764-7
Softcover ISBN
978-94-017-8099-5
Series ISSN
0306-0225
Edition Number
1
Number of Pages
VIII, 300
Topics