The Tumor Microenvironment

Tumor Ablation

Effects on Systemic and Local Anti-Tumor Immunity and on Other Tumor-Microenvironment Interactions

Editors: Keisari, Yona (Ed.)

  • Comprehensive description and comparison of tumor ablation methods
  • Conceptual and practical aspects of cancer immunotherapy
  • Combination treatments of cancer
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eBook $169.00
price for USA (gross)
  • ISBN 978-94-007-4694-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
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  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-94-007-4693-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-94-007-9932-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The growing knowledge on tumor-immune response interactions and on the tumor microenvironment did not translate so far into better control of cancer by anti-tumor vaccination. The percentage of patients who benefited from vaccination strategies is still too small to justify their general use. It is the aim of this book to present an alternative to the conventional approach of developing injected tumor vaccines to activate anti-tumor immunity, which will fight cancer. It is argued that in situ tumor ablation (destruction) that involves tumor antigen release; cross presentation and the release of danger associated molecular patterns (DAMPs) can make the tumor its own cellular vaccine.

Tumor ablation methods using chemicals, radiation, photodynamic therapy, cryoablation, high-temperature, radiofrequency, high intensity focused ultrasound, and electric-based ablation have been developed for focal tumors. In this book experts will deal with two main topics: I. What are the principles of the various ablation modalities, and II. How each method affects the tumor cells and their microenvironment, and how these effects are responsible for the induction of specific anti-tumor immunity.

The aims of this book are thus: 1. Familiarize the readers with various methods of in situ tumor ablation. 2. Review the literature and stimulate comparisons on the efficacy of different ablation methods for the treatment of tumors of different histotypes. 3. Review the literature on the effects of various ablation methods on systemic and local anti tumor immunity and on other manifestations of the interactions of tumors with their microenvironment. 4. Stimulate comparative studies on the immunostimulatory effects of different ablation modalities.

Table of contents (8 chapters)

  • Effect of Chemotherapy on the Tumor Microenvironment and Anti-tumor Immunity

    Meniawy, Tarek M. (et al.)

    Pages 1-28

  • Hyperthermia, the Tumor Microenvironment and Immunity

    Calderwood, Stuart K.

    Pages 29-37

  • Radiofrequency Ablation in Cancer Therapy: Tuning in to in situ Tumor Vaccines

    Nierkens, Stefan (et al.)

    Pages 39-59

  • High Intensity Focused Ultrasound (HIFU) Ablation

    Wu, Feng

    Pages 61-75

  • The Interrelationship Between Cryoablation, the Immune Response and the Tumor Microenvironment: Stimulatory and Suppressive Effects

    Sabel, Michael S.

    Pages 77-107

Buy this book

eBook $169.00
price for USA (gross)
  • ISBN 978-94-007-4694-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.00
price for USA
  • ISBN 978-94-007-4693-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.00
price for USA
  • ISBN 978-94-007-9932-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Tumor Ablation
Book Subtitle
Effects on Systemic and Local Anti-Tumor Immunity and on Other Tumor-Microenvironment Interactions
Editors
  • Yona Keisari
Series Title
The Tumor Microenvironment
Series Volume
5
Copyright
2013
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-007-4694-7
DOI
10.1007/978-94-007-4694-7
Hardcover ISBN
978-94-007-4693-0
Softcover ISBN
978-94-007-9932-5
Edition Number
1
Number of Pages
XII, 156
Topics