SpringerBriefs in Biochemistry and Molecular Biology

The Chaperonopathies

Diseases with Defective Molecular Chaperones

Authors: Macario, Alberto J.L., Conway de Macario, Everly, Cappello, Francesco

  • A unique and comprehensive survey and description of diseases, the chaperonopathies, in which molecular chaperones are etiologic-pathogenic factors
  • An easy-to-grasp, well-illustrated with tables and figures, panoramic view of the state-of-the-art analysis of chaperonopathies
  • Unveils new routes to diagnose chaperonopathies, establish prognosis, treat and manage ¬†patients properly, thereby showing the path for future research
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eBook $39.99
price for USA (gross)
  • ISBN 978-94-007-4667-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $49.99
price for USA
  • ISBN 978-94-007-4666-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments. 

Table of contents (9 chapters)

  • Overview and Book Plan

    Macario, Alberto J.L (et al.)

    Pages 1-14

  • Chaperones: General Characteristics and Classifications

    Macario, Alberto J.L (et al.)

    Pages 15-33

  • The Chaperonopathies: Classification, Mechanisms, Structural Features

    Macario, Alberto J.L (et al.)

    Pages 35-42

  • Structural and Hereditary Chaperonopathies: Mutation

    Macario, Alberto J.L (et al.)

    Pages 43-62

  • Other Genetic Chaperonopathies

    Macario, Alberto J.L (et al.)

    Pages 63-69

Buy this book

eBook $39.99
price for USA (gross)
  • ISBN 978-94-007-4667-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $49.99
price for USA
  • ISBN 978-94-007-4666-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Chaperonopathies
Book Subtitle
Diseases with Defective Molecular Chaperones
Authors
Series Title
SpringerBriefs in Biochemistry and Molecular Biology
Copyright
2013
Publisher
Springer Netherlands
Copyright Holder
The Author(s)
eBook ISBN
978-94-007-4667-1
DOI
10.1007/978-94-007-4667-1
Softcover ISBN
978-94-007-4666-4
Series ISSN
2211-9353
Edition Number
1
Number of Pages
XVI, 116
Number of Illustrations and Tables
3 b/w illustrations, 23 illustrations in colour
Topics