Subcellular Biochemistry

The Eukaryotic Replisome: a Guide to Protein Structure and Function

Editors: MacNeill, Stuart (Ed.)

  • Takes the reader on a guided tour of the structural biology of the eukaryotic DNA replication machinery, the first time that this has been done in a single volume
  • Individual chapters focusing on the three-dimensional structure and function of key components written by leading experts in the field
  • An additional chapter providing a comprehensive overview of the evolutionary distribution of key proteins and protein complexes.
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eBook $229.00
price for USA (gross)
  • ISBN 978-94-007-4572-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.00
price for USA
  • ISBN 978-94-007-4571-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $299.00
price for USA
  • ISBN 978-94-007-9770-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.

Table of contents (17 chapters)

  • Composition and Dynamics of the Eukaryotic Replisome: A Brief Overview

    MacNeill, Stuart

    Pages 1-17

  • Evolutionary Diversification of Eukaryotic DNA Replication Machinery

    Aves, Stephen J. (et al.)

    Pages 19-35

  • The Origin Recognition Complex: A Biochemical and Structural View

    Li, Huilin (et al.)

    Pages 37-58

  • Archaeal Orc1/Cdc6 Proteins

    Bell, Stephen D.

    Pages 59-69

  • Cdt1 and Geminin in DNA Replication Initiation

    Caillat, Christophe (et al.)

    Pages 71-87

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-94-007-4572-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $299.00
price for USA
  • ISBN 978-94-007-4571-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $299.00
price for USA
  • ISBN 978-94-007-9770-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Eukaryotic Replisome: a Guide to Protein Structure and Function
Editors
  • Stuart MacNeill
Series Title
Subcellular Biochemistry
Series Volume
62
Copyright
2012
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-007-4572-8
DOI
10.1007/978-94-007-4572-8
Hardcover ISBN
978-94-007-4571-1
Softcover ISBN
978-94-007-9770-3
Series ISSN
0306-0225
Edition Number
1
Number of Pages
VIII, 348
Topics