Pediatric Cancer

Pediatric Cancer, Volume 3

Diagnosis, Therapy, and Prognosis

Editors: Hayat, M.A. (Ed.)

  • Results of treatments are also presented in color figures
  • Various therapies against cancer are explained
  • Most recent diagnostic and therapeutic information is provided
  • Information on the development of new, more effective drugs is included
  • Translational and personal target treatments are given
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eBook $189.00
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  • ISBN 978-94-007-4528-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-94-007-4527-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Brain tumors are the most common solid tumor of childhood as well as the leading cause of cancer-related mortality in children. This third volume of the Springer series discussing pediatric cancer focuses on diagnosing, treating, and assessing the future course of malignant brain neoplasms in children. In addition to a general introduction to the principals involved, the material includes vital research in molecular genetics, a major contribution to the molecular characterization of solid tumors, which will define new biomarkers of the disease and identify molecular pathways. Now it has become possible to achieve the goal of targeting new, more effective therapies to minimize the tragedy faced by children. This research features the application of molecular genetics in combating atypical teratoid/rhabdoid tumor (AT/RT), a highly aggressive embryonal CNS tumor that is among the most common malignant neoplasms in children, with a peak occurrence in infants younger than three years old.

Contributors also examine the reasons for the common misdiagnosis of AT/RT tumors as other types of CNS tumors. They help resolve this issue by indicating the details of an abnormality in the genetics of AT/RT, which is unique to AT/RT type. The INII gene on chromosome 22q11 is involved in the AT/RT. The presence of this gene and the SMARCB1 is discussed. In addition to discussing these important topics, the volume includes presentations of present and future therapies. The volume also explains AT/RT’s dissemination to the cerebral fluid, the molecular mechanisms underlying the progression of medulloblastoma, and the importance of gamma knife radiosurgery during multimodality management of medulloblastoma/PNET tumors. Other topics discussed include using magnetic resonance imaging for diagnosing retinoblastoma, and mapping the effects of radiotherapy in low-grade glioma in children. Information on alterations in cell-cycle regulators that are influenced by tumor suppressor genes and oncogenes is detailed. Contributors provide recommendations concerning non-narcotic analgesic routines for children recovering from cranial and spinal surgery. The practical knowledge of frontier-expanding research presented leads this authoritative volume to be a compelling addition to the literature.

Table of contents (31 chapters)

  • Early Childhood Atypical Teratoid/Rhabdoid Tumors

    Haberler, Christine (et al.)

    Pages 3-12

  • Atypical Teratoid/Rhabdoid Tumors

    Sredni, Simone Treiger (et al.)

    Pages 13-24

  • Paediatric Teratoid/Rhabdoid Tumours: Germline Deletions of Chromosome 22q11.2

    Beddow, Rachel

    Pages 25-34

  • Pediatric Atypical Teratoid/Rhabdoid Tumor: Role of INI1 Tumor Suppressor Gene

    Coccé, Mariela Carolina (et al.)

    Pages 35-44

  • Atypical Teratoid/Rhabdoid Tumors: Diagnosis Using Imaging

    Arslanoglu, Atilla

    Pages 45-53

Buy this book

eBook $189.00
price for USA (gross)
  • ISBN 978-94-007-4528-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $239.00
price for USA
  • ISBN 978-94-007-4527-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Pediatric Cancer, Volume 3
Book Subtitle
Diagnosis, Therapy, and Prognosis
Editors
  • M.A. Hayat
Series Title
Pediatric Cancer
Series Volume
3
Copyright
2012
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-007-4528-5
DOI
10.1007/978-94-007-4528-5
Hardcover ISBN
978-94-007-4527-8
Series ISSN
2211-7997
Edition Number
1
Number of Pages
XXXI, 301
Topics