Subcellular Biochemistry

Epigenetics: Development and Disease

Editors: Kundu, Tapas Kumar (Ed.)

  • Role of genome organisation as a basic platform of different epigenetic phenomena in the pathophysiological context
  • Epigenetic regulation of transcription Epigenetic contribution in development
  • Epigenetic mechanisms of important diseases such as diabetes, AIDS, Alzheimer?s disease, malaria and cancer Furthermore, the book has also revealed the epigenetic phenomena as target of new generation therapeutics
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eBook $269.00
price for USA (gross)
  • ISBN 978-94-007-4525-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.00
price for USA
  • ISBN 978-94-007-4524-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies. This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.

Table of contents (28 chapters)

  • Chromatin Organization, Epigenetics and Differentiation: An Evolutionary Perspective

    Kumari, Sujata (et al.)

    Pages 3-35

  • Secondary Structures of the Core Histone N-terminal Tails: Their Role in Regulating Chromatin Structure

    Preez, Louis L. (et al.)

    Pages 37-55

  • Megabase Replication Domains Along the Human Genome: Relation to Chromatin Structure and Genome Organisation

    Audit, Benjamin (et al.)

    Pages 57-80

  • Role of DNA Methyltransferases in Epigenetic Regulation in Bacteria

    Kumar, Ritesh (et al.)

    Pages 81-102

  • Metabolic Aspects of Epigenome: Coupling of S-Adenosylmethionine Synthesis and Gene Regulation on Chromatin by SAMIT Module

    Igarashi, Kazuhiko (et al.)

    Pages 105-118

Buy this book

eBook $269.00
price for USA (gross)
  • ISBN 978-94-007-4525-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.00
price for USA
  • ISBN 978-94-007-4524-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Epigenetics: Development and Disease
Editors
  • Tapas Kumar Kundu
Series Title
Subcellular Biochemistry
Series Volume
61
Copyright
2013
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-007-4525-4
DOI
10.1007/978-94-007-4525-4
Hardcover ISBN
978-94-007-4524-7
Series ISSN
0306-0225
Edition Number
1
Number of Pages
XXVI, 689
Topics