Advances in Experimental Medicine and Biology

Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium

Editors: Toman, R., Heinzen, R.A., Samuel, J.E., Mege, J.-L. (Eds.)

  • Provides the reader interesting insights into highly infectious intracellular pathogen Coxiella burnetii, the causative agent of Q fever, summarized by several leading groups in the field
  • Includes the newest data, techniques, and methodologies that have substantially transformed our understanding of the pathogen
  • Useful for microbiologists as well as veterinarians, physicians and health authorities involved in clinical medicine, emerging disease surveillance and biodefense.
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eBook $219.00
price for USA (gross)
  • ISBN 978-94-007-4315-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-94-007-4314-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA
  • ISBN 978-94-007-9205-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Coxiella burnetii is the etiological agent of Q fever, a zoonotic disease found worldwide. The bacterium is a fascinating example of intracellular parasitism that has uniquely evolved to thrive in the most inhospitable of cellular compartments-the phagolysosome. Understanding how C. burnetii resists the degradative functions of this vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen. Several chapters survey immune functions that control or potentially exacerbate Coxiella infection and delve into correlates of protective immunity elicited by vaccination. Comparative genomics is also the foundation of chapters discussing diagnostic antigen discovery and molecular typing of the bacterium, with significance for development of new clinical, epidemiologic, and forensic tools.

Table of contents (19 chapters)

  • History and Prospects of Coxiella burnetii Research

    Hechemy, Karim E.

    Pages 1-11

  • Phylogenetic Diversity, Virulence and Comparative Genomics

    Schaik, Erin J. (et al.)

    Pages 13-38

  • Defense Mechanisms Against Oxidative Stress in Coxiella burnetii: Adaptation to a Unique Intracellular Niche

    Mertens, Katja (et al.)

    Pages 39-63

  • Lipopolysaccharide of Coxiella burnetii

    Narasaki, Craig T. (et al.)

    Pages 65-90

  • Components of Protective Immunity

    Zhang, Guoquan (et al.)

    Pages 91-104

Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-94-007-4315-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-94-007-4314-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA
  • ISBN 978-94-007-9205-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium
Editors
  • Rudolf Toman
  • Robert A. Heinzen
  • James E. Samuel
  • Jean-Louis Mege
Series Title
Advances in Experimental Medicine and Biology
Series Volume
984
Copyright
2012
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media Dordrecht
eBook ISBN
978-94-007-4315-1
DOI
10.1007/978-94-007-4315-1
Hardcover ISBN
978-94-007-4314-4
Softcover ISBN
978-94-007-9205-0
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIV, 406
Topics