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Midkine: From Embryogenesis to Pathogenesis and Therapy

  • Book
  • © 2012

Overview

Editors:
  1. Mine Ergüven

    1. Faculty of Medicine, Faculty of Biochemistry, Yeni Yüzyıl University, Istanbul, Turkey

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    You can also search for this editor in PubMed   Google Scholar

  2. Takashi Muramatsu

    1. , Department of Health Science, Aichi Gakuin University, Nisshin, Japan

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    You can also search for this editor in PubMed   Google Scholar

  3. Ayhan Bilir

    1. , Department of Histology and Embryology, Istanbul University Faculty of Medicine, Istanbul, Turkey

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Comprehensive coverage of old, but newly pronounced protein midkine as a promising prognostic and diagnostic biomarker, and a therapeutic agent in wide range of diseases
  • Provides an information about the techniques that are used in studying midkine
  • Leading experts present their latest work in addition to extensive up-to-date literature review

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-ix
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  2. General Aspects of Midkine

    1. Front Matter

      Pages 1-1
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  3. GENERAL ASPECTS OF MIDKINE

    1. General Information on Midkine

      • Takashi Muramatsu
      Pages 3-13

    2. The Role of Midkine in Neural Development and Patterning

      • Sheng Yao, Christoph Winkler
      Pages 15-28

    3. Midkine: A Player in Innate Immunity

      • Sara L. Nordin, Arne Egesten
      Pages 29-39

    4. Midkine/P63 Axis in Regulation of Epithelial-Mesenchymal Transition

      • Yiping Huang, Edward A. Ratovitski
      Pages 41-52

    5. Immunochemical Methods for the Detection of Midkine in Samples of Human Origin

      • Stefan Sommerschuh, Michael Kirchner, Nicole Gliese
      Pages 53-67

    6. Circulating Midkine in Malignant, Inflammatory, and Infectious Diseases: A Systematic Review

      • Malgorzata Krzystek-Korpacka, Malgorzata Matusiewicz
      Pages 69-85

  4. Midkine and Inflammation

    1. Front Matter

      Pages 87-87
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  5. MIDKINE AND INFLAMMATION

    1. Midkine in Inflammation and Inflammatory Diseases

      • Nuray Yazıhan, Mehtap Kacar Kocak, Ethem Akcıl
      Pages 89-101

    2. Rheumatoid Arthritis and Midkine

      • Hisako Muramatsu, Kiyoko Maruyama, Naoki Ishiguro
      Pages 103-109

  6. Midkine and the Cardiovascular System

    1. Front Matter

      Pages 111-111
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  7. MIDKINE AND THE CARDIOVASCULAR SYSTEM

    1. Midkine and Heart Failure

      • Mitsuru Horiba, Kenji Kadomatsu
      Pages 113-124

    2. Vascular Restenosis and Midkine

      • Kenji Kadomatsu
      Pages 125-130

    3. The Potential of MK Through the Renin-Angiotensin System

      • Tomoki Kosugi, Kenji Kadomatsu
      Pages 131-140

  8. Midkine and the Nervous System

    1. Front Matter

      Pages 141-141
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  9. MIDKINE AND THE NERVOUS SYSTEM

    1. Midkine and Multiple Sclerosis

      • Hideyuki Takeuchi
      Pages 143-151

    2. Midkine Gene Transfer in Brain Infarction

      • Hiroaki Ooboshi, Eiichi Ishikawa, Junichi Takada, Takashi Shichita, Yasuhiro Kumai
      Pages 153-163

    3. Midkine in Psychiatric and Neurodegenerative Diseases

      • Eiji Shimizu, Daisuke Matsuzawa
      Pages 165-170

  10. Midkine and the Urogenital System, Reproduction and Aging

    1. Front Matter

      Pages 171-171
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Keywords

About this book

Carl Edward Sagan’s (1934-1996) one of the famous quotation was “Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.“ From past to date, well-known molecules, enzymes, proteins, lipids and carbohydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgotten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named “Midkine” This book summarizes the extensive up-to-date literature overeview with the lastest work of experts about midkine in a detailed format that conveys its role as botha pathologic factor and therapeutic agent.

Editors and Affiliations

  • Faculty of Medicine, Faculty of Biochemistry, Yeni Yüzyıl University, Istanbul, Turkey

    Mine Ergüven

  • , Department of Health Science, Aichi Gakuin University, Nisshin, Japan

    Takashi Muramatsu

  • , Department of Histology and Embryology, Istanbul University Faculty of Medicine, Istanbul, Turkey

    Ayhan Bilir

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