Mechanical Stretch and Cytokines

1. Front Matter

   Pages i-xv

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2. Cytokine System

   • Andrey S. Simbirtsev, Ivan G. Kozlov

   Pages 1-33

3. Mechanical Stretching of Cells of Different Tissues: The Role of Mediators of Innate Immunity

   • Leonid V. Kovalchuk, Marina V. Khoreva, Anna Nikonova, Viktor E. Kazanski, Ilya Lozinsky, Irina N. D’iakonova et al.

   Pages 35-58

4. Mechanosensitive Pro-inflammatory Gene Expression in Vascular Cells

   • Marco Cattaruzza, Andreas H. Wagner, Markus Hecker

   Pages 59-86

5. Cytokines, Heart and Calcium Current in Sepsis

   • Milan Stengl, Miroslav Prucha, Martin Matejovic

   Pages 87-106

6. The Role of Proinflammatory Cytokines in Regulation of Cardiac Bioelectrical Activity: Link to Mechanoelectrical Feedback

   • Vlad S. Kuzmin, Denis V. Abramochkin, Vadim M. Mitrochin, Bo Tian, Ekaterina Yu. Makarenko, Leonid V. Kovalchuk et al.

   Pages 107-153

7. An Anti-inflammatory Cytokine Interleukin-13: Physiological Role in the Heart and Mechanoelectrical Feedback

   • Denis V. Abramochkin, Ekaterina Yu. Makarenko, Vadim M. Mitrochin, Bo Tian, Vlad S. Kuzmin, Leonid Kalugin et al.

   Pages 155-164

8. Mechanical Stretch and Cytokine Synthesis in Pulmonary Endothelial Cells

   • Satoru Ito, Yoshinori Hasegawa

   Pages 165-187

9. Implications of Cytokines in Cochlear Pathophysiology

   • Keiji Tabuchi, Akira Hara

   Pages 189-199

10. Primary Cilia are Mechanosensory Organelles with Chemosensory Roles

    • Brian S. Muntean, Xingjian Jin, Surya M. Nauli

    Pages 201-222

11. Identification of Mechanosensitive Genes in Chondrocytes and Osteoblasts and Their Role in OA Pathogenesis

    • Yves Henrotin, Laurence Pesesse, Christelle Sanchez

    Pages 223-233

12. Back Matter

    Pages 235-236

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This book presents the latest findings in the field of investigation of molecular mechanisms of mechanical stretch and the role of cytokines in response of different tissues to it. On the one hand this Volume demonstrates how mechanical stretch enhances cytokines production. It describes how cytokines influence tissues and cells on a background of a mechanical stretching. It provides a description of how cells in different tissues are activated by stretch and cytokines via various signaling pathways, and how they change their gene expression. The book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Knowledge of biomechanics, and mechanisms which underlie it on molecular, cellular and tissue, is necessary for understanding of the normal functioning of living organisms and allows to predict changes, which arise due to alterations of their environment.

• Cells
• Cytokines
• Mechanosensitivity
• Stretch activated currents
• Stretch induced potentials

• Dept. Fundamental &, Applied Physiology, Russian State Medical University, Moskva, Russian Federation

  Andre Kamkin

• , Department of Fundamental and Applied Ph, Russian State Medical University, Moscow, Russian Federation

  Irina Kiseleva

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