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Mechanosensitivity of the Heart

  • Book
  • © 2010

Overview

Editors:
  1. Andre Kamkin

    1. Dept. Fundamental &, Russian State Medical University, Moskva, Russian Federation

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  2. Irina Kiseleva

    1. Dept. Fundamental &, Russian State Medical University, Moskva, Russian Federation

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    You can also search for this editor in PubMed   Google Scholar

  • This is the first series of books that considers the problem of cell mechanosensitivity of organs and tissues at the molecular, biological, bio-physical, physiological and pharmacological levels and draws the attention to the global problem of the mechanosensitivity and its mechanisms
  • In addition, the problem of intracellular crosstalk (i.e. a network of mechanically induced intracellular signaling cascades) is discussed for the first time

Part of the book series: Mechanosensitivity in Cells and Tissues (MECT, volume 3)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xxxix
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  2. Molecular Mechanisms of Mechanotransduction in Cardiac Cells

    1. Front Matter

      Pages 1-1
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    2. Titin and Titin-Associated Proteins in Myocardial Stress-Sensing and Mechanical Dysfunction

      • Wolfgang A. Linke
      Pages 3-34

    3. Mechanical Stretch-Induced Reorganization of the Cytoskeleton and the Small GTPase Rac-1 in Cardiac Fibroblasts

      • Wayne Carver, John W. Fuseler
      Pages 35-54

    4. Molecular Signaling Mechanisms of Myocardial Stretch: Implications for Heart Disease

      • Hind Lal, Suresh K. Verma, Honey B. Golden, Donald M. Foster, April M. Holt, David E. Dostal
      Pages 55-81

    5. Mechanical Stress Induces Cardiomyocyte Hypertrophy Through Agonist-Independent Activation of Angiotensin II Type 1 Receptor

      • Hiroshi Akazawa, Issei Komuro
      Pages 83-95

  3. Mechanically Induced Potentials and Currents of the Cardiac Cells in Healthy and Diseased Myocardium

    1. Front Matter

      Pages 97-97
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    2. Mechanostransduction in Cardiac and Stem-Cell Derived Cardiac Cells

      • Jeffrey G. Jacot, Anna J. Raskin, Jeffrey H. Omens, Andrew D. McCulloch, Leslie Tung
      Pages 99-139

    3. Stretch-Activated Channels in the Heart: Contribution to Cardiac Performance

      • Marie-Louise Ward, David G. Allen
      Pages 141-167

    4. Effects of Applied Stretch on Native and Recombinant Cardiac Na+ Currents

      • Umberto Banderali, Robert B. Clark, Catherine E. Morris, Martin Fink, Wayne R. Giles
      Pages 169-184

    5. Mechanosensitive Alterations of Action Potentials and Membrane Currents in Healthy and Diseased Cardiomyocytes: Cardiac Tissue and Isolated Cell

      • Ilya Lozinsky, Andre Kamkin
      Pages 185-238

    6. The Role of Mechanosensitive Fibroblasts in the Heart: Evidence from Acutely Isolated Single Cells, Cultured Cells and from Intracellular Microelectrode Recordings on Multicellular Preparations from Healthy and Diseased Cardiac Tissue

      • Andre Kamkin, Irina Kiseleva, Ilya Lozinsky
      Pages 239-266

    7. Scanning Ion Conductance Microscopy for Imaging and Mechanosensitive Activation of Selected Areas of Live Cells

      • Max J. Lab
      Pages 267-272

  4. Mechano-Electric Feedback in the Whole Heart and a Computer Simulation Study

    1. Front Matter

      Pages 272-272
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    2. The Contribution of MEF to Electrical Heterogeneity and Arrhythmogenesis

      • David A. Saint, Douglas Kelly, Lorraine Mackenzie
      Pages 275-300

    3. Mechanical Modulation of a Reentrant Arrhythmia: The Atrial Flutter Case

      • Flavia Ravelli, Michela Masè
      Pages 301-325

    4. Early Hypertrophic Signals After Myocardial Stretch. Role of Reactive Oxygen Species and the Sodium/Hydrogen Exchanger

      • Horacio E. Cingolani, Néstor G. Pérez, Claudia I. Caldiz, Carolina D. Garciarena, Verónica C. De Giusti, María V. Correa et al.
      Pages 327-371

    5. Stretch-Induced Inotropy in Atrial and Ventricular Myocardium

      • Dirk von Lewinski, Jens Kockskämper, Mounir Khafaga, Robert Gasser, Burkert Pieske
      Pages 373-385

    6. Effects of Wall Stress on the Dynamics of Ventricular Fibrillation: A Computer Simulation Study of Mechanoelectric Feedback

      • Satoko Hirabayashi, Masashi Inagaki, Toshiaki Hisada, Masaru Sugimachi
      Pages 387-419

    7. Electromechanical Modelling of Cardiac Tissue

      • C. Cherubini, S. Filippi, P. Nardinocchi, L. Teresi
      Pages 421-449
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Editors and Affiliations

  • Dept. Fundamental &, Russian State Medical University, Moskva, Russian Federation

    Andre Kamkin, Irina Kiseleva

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