Phosphoinositides II: The Diverse Biological Functions

1. Front Matter

   Pages 1-1

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2. Ca2+ Signalling by IP3 Receptors

   • Colin W. Taylor, David L. Prole

   Pages 1-34

3. Phosphoinositide Signaling During Membrane Transport in Saccharomyces Cerevisiae

   • Amber L. Schuh, Anjon Audhya

   Pages 35-63

4. Phosphoinositides in the Mammalian Endo-lysosomal Network

   • Peter J. Cullen, Jeremy G. Carlton

   Pages 65-110

5. Role of PI(4,5)P2 in Vesicle Exocytosis and Membrane Fusion

   • Thomas F.J. Martin

   Pages 111-130

6. Role of Phosphoinositides at the Neuronal Synapse

   • Samuel G. Frere, Belle Chang-Ileto, Gilbert Di Paolo

   Pages 131-175

7. Phosphatidylinositol 4, 5 Bisphosphate and the Actin Cytoskeleton

   • Li Zhang, Yuntao S. Mao, Paul A. Janmey, Helen L. Yin

   Pages 177-215

8. Phosphoinositides in Chemotaxis

   • Michael C. Weiger, Carole A. Parent

   Pages 217-254

9. Phosphoinositides in Golgi Complex Function

   • Giovanni D’Angelo, Mariella Vicinanza, Cathal Wilson, Maria Antonietta De Matteis

   Pages 255-270

10. Sec14 Like PITPs Couple Lipid Metabolism with Phosphoinositide Synthesis to Regulate Golgi Functionality

    • Carl J. Mousley, James M. Davison, Vytas A. Bankaitis

    Pages 271-287

11. Phosphoinositide Sensitivity of Ion Channels, a Functional Perspective

    • Nikita Gamper, Tibor Rohacs

    Pages 289-333

12. Nuclear Phosphoinositides: Location, Regulation and Function

    • Roberta Fiume, Willem Jan Keune, Irene Faenza, Yvette Bultsma, Giulia Ramazzotti, David R. Jones et al.

    Pages 335-361

13. Phosphoinositides and Cellular Pathogens

    • Bernard Payrastre, Frédérique Gaits-Iacovoni, Philippe Sansonetti, Hélène Tronchère

    Pages 363-388

14. Defining Signal Transduction by Inositol Phosphates

    • Stephen B. Shears, Sindura B. Ganapathi, Nikhil A. Gokhale, Tobias M. H. Schenk, Huanchen Wang, Jeremy D. Weaver et al.

    Pages 389-412

15. Cell Signalling by Inositol Pyrophosphates

    • Adolfo Saiardi

    Pages 413-443

16. Back Matter

    Pages 439-439

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Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.

• PI 3-kinase
• PTEN
• kinase
• phosphatase
• phosphoinositide

• , NICHD, National Institutes of Health, Bethesda, USA

  Tamas Balla

• , Cancer- and Immunobiology, University of Basel, Basel, Switzerland

  Matthias Wymann

• , Pharmacology and Cancer Biology, Duke University Medical Center, Durham, USA

  John D. York

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