Subcellular Biochemistry

Phosphoinositides I: Enzymes of Synthesis and Degradation

Editors: Balla, Tamas, Wymann, Matthias, York, John D. (Eds.)

  • In depth discussion of the state of the art of phosphoinositide research
  • Experts in the field discussing the 'hot' topics in phosphoinositide research
  • A volume dedicated to the enzymes involved in the synthesis and degradation of phosphoinositides
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eBook $199.00
price for USA (gross)
  • ISBN 978-94-007-3012-0
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  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-94-007-3011-3
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  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
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  • ISBN 978-94-017-8157-2
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About this book

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Table of contents (9 chapters)

  • The Phosphatidylinositol 4-Kinases: Don’t Call it a Comeback

    Minogue, Shane (et al.)

    Pages 1-24

  • PIP Kinases from the Cell Membrane to the Nucleus

    Schramp, Mark (et al.)

    Pages 25-59

  • The Phospholipase C Isozymes and Their Regulation

    Gresset, Aurelie (et al.)

    Pages 61-94

  • Phosphoinositide 3-Kinases—A Historical Perspective

    Toker, Alex

    Pages 95-110

  • PI3Ks—Drug Targets in Inflammation and Cancer

    Wymann, Matthias

    Pages 111-181

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-94-007-3012-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-94-007-3011-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-94-017-8157-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Phosphoinositides I: Enzymes of Synthesis and Degradation
Editors
  • Tamas Balla
  • Matthias Wymann
  • John D. York
Series Title
Subcellular Biochemistry
Series Volume
58
Copyright
2012
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-94-007-3012-0
DOI
10.1007/978-94-007-3012-0
Hardcover ISBN
978-94-007-3011-3
Softcover ISBN
978-94-017-8157-2
Series ISSN
0306-0225
Edition Number
1
Number of Pages
XVI, 356
Topics