Advances in Experimental Medicine and Biology

Advances in Mitochondrial Medicine

Editors: Scatena, Roberto, Bottoni, Patrizia, Giardina, Bruno (Eds.)

  • Discusses the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses
  • Follows a scientific approach to asses the complex and heterogenious relationships between mitochondria and calcium, apoptosis, oxidative phosphorylation, Reactive Oxygen Species and anabolic pathways
  • Discusses mitochondria as a valuable target for xenobiotics and its etiopathogenic role in neglected iatrogenic diseases, stimulating the use of existing knowledge for clinical applications, diagnosis and therapy
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eBook $219.00
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  • ISBN 978-94-007-2869-1
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Hardcover $279.00
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About this book

Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.

Table of contents (20 chapters)

  • The Oxidative Phosphorylation System in Mammalian Mitochondria

    Papa, Sergio (et al.)

    Pages 3-37

  • Physiology and Pathophysiology of Mitochondrial DNA

    Li, Hongzhi (et al.)

    Pages 39-51

  • Mitochondrial Ca2+ as a Key Regulator of Mitochondrial Activities

    Calì, Tito (et al.)

    Pages 53-73

  • Mitochondria and Nitric Oxide: Chemistry and Pathophysiology

    Sarti, Paolo (et al.)

    Pages 75-92

  • Mitochondria and Reactive Oxygen Species. Which Role in Physiology and Pathology?

    Lenaz, Giorgio

    Pages 93-136

Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-94-007-2869-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-94-007-2868-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Advances in Mitochondrial Medicine
Editors
  • Roberto Scatena
  • Patrizia Bottoni
  • Bruno Giardina
Series Title
Advances in Experimental Medicine and Biology
Series Volume
942
Copyright
2012
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-94-007-2869-1
DOI
10.1007/978-94-007-2869-1
Hardcover ISBN
978-94-007-2868-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XII, 461
Topics