SpringerBriefs in Neuroscience

Induced Pluripotent Stem Cells in Brain Diseases

Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine.

Authors: Heine, V.M., Dooves, S., Holmes, D., Wagner, J.

  • Up-to-date review on the latest reprogramming techniques
  • Comprehensive overview of the epigenetic models and how these will help us to map cell identity, plasticity and fate
  • Current state and issues on induced pluripotent stem cells in cell therapies for brain diseases​
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eBook $34.99
price for USA (gross)
  • ISBN 978-94-007-2816-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $49.95
price for USA
  • ISBN 978-94-007-2815-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic “memories” of what they were that can affect reprogramming. This book discusses the various methods to reprogram cells, the control and determination of cell identity, the epigenetic models that have emerged and the application of iPS cell therapy for brain diseases, in particular Parkinson’s disease and Vanishing White Matter (VWM).​

About the authors

Dr. Vivi M. Heine is an assistant professor in the Department of Pediatrics of the VU University Medical Center in Amsterdam, Netherlands. Dr. Heine earned her doctoral degree in Neurobiology from the University of Amsterdam, Netherlands. She then received post-doctoral training at the Dana Farber Cancer Institute, Harvard University, Boston and at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California at San Francisco. She obtained a tenure track position in 2010.

Table of contents (4 chapters)

  • Reprogramming: A New Era in Regenerative Medicine

    Heine, Vivi M. (et al.)

    Pages 1-25

  • Understanding Epigenetic Memory is the Key to Successful Reprogramming

    Heine, Vivi M. (et al.)

    Pages 27-41

  • Prospects for Cell Replacement Therapies for Neurodegenerative Diseases

    Heine, Vivi M. (et al.)

    Pages 43-54

  • Conclusions

    Heine, Vivi M. (et al.)

    Pages 55-59

Buy this book

eBook $34.99
price for USA (gross)
  • ISBN 978-94-007-2816-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $49.95
price for USA
  • ISBN 978-94-007-2815-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Induced Pluripotent Stem Cells in Brain Diseases
Book Subtitle
Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine.
Authors
Series Title
SpringerBriefs in Neuroscience
Copyright
2012
Publisher
Springer Netherlands
Copyright Holder
The Author(s)
eBook ISBN
978-94-007-2816-5
DOI
10.1007/978-94-007-2816-5
Softcover ISBN
978-94-007-2815-8
Series ISSN
2191-558X
Edition Number
1
Number of Pages
XV, 59
Number of Illustrations and Tables
1 b/w illustrations, 6 illustrations in colour
Topics