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Aging Research in Yeast

  • Book
  • © 2012

Overview

Editors:
  1. Michael Breitenbach

    1. , Department of Cell Biology, University of Salzburg, Salzburg, Austria

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  2. S. Michal Jazwinski

    1. , Tulane Center for Aging and Department o, Tulane University Health Sciences Center, New Orleans, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Peter Laun

    1. , Department of Cell Biology, University of Salzburg, Salzburg, Austria

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    You can also search for this editor in PubMed   Google Scholar

  • Yeast aging research and its relevance to humans
  • Thorough account of a rapidly expanding field
  • Offers a molecular cell biology perspective on aging
  • Written by authorities in the field of aging research

Part of the book series: Subcellular Biochemistry (SCBI, volume 57)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xii
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  2. Introduction

    • Michael Breitenbach, Peter Laun, S. Michal Jazwinski
    Pages 1-12

  3. Oxidative Stresses and Ageing

    • May T. Aung-Htut, Anita Ayer, Michael Breitenbach, Ian W. Dawes
    Pages 13-54

  4. The Role of Mitochondria in the Aging Processes of Yeast

    • Michael Breitenbach, Peter Laun, J. Richard Dickinson, Andrea Klocker, Mark Rinnerthaler, Ian W. Dawes et al.
    Pages 55-78

  5. The Retrograde Response and Other Pathways of Interorganelle Communication in Yeast Replicative Aging

    • S. Michal Jazwinski
    Pages 79-100

  6. Chronological Aging in Saccharomyces cerevisiae

    • Valter D. Longo, Paola Fabrizio
    Pages 101-121

  7. Aging and the Survival of Quiescent and Non-quiescent Cells in Yeast Stationary-Phase Cultures

    • M. Werner-Washburne, Sushmita Roy, George S. Davidson
    Pages 123-143

  8. Maximising the Yeast Chronological Lifespan

    • Peter W. Piper
    Pages 145-159

  9. Amino Acid Homeostasis and Chronological Longevity in Saccharomyces cerevisiae

    • John P. Aris, Laura K. Fishwick, Michelle L. Marraffini, Arnold Y. Seo, Christiaan Leeuwenburgh, William A. Dunn Jr.
    Pages 161-186

  10. DNA Damage and DNA Replication Stress in Yeast Models of Aging

    • William C. Burhans, Martin Weinberger
    Pages 187-206

  11. Yeast Aging and Apoptosis

    • Peter Laun, Sabrina Büttner, Mark Rinnerthaler, William C. Burhans, Michael Breitenbach
    Pages 207-232

  12. Cellular Homeostasis in Fungi: Impact on the Aging Process

    • Christian Q. Scheckhuber, Andrea Hamann, Diana Brust, Heinz D. Osiewacz
    Pages 233-250

  13. Genome-Wide Analysis of Yeast Aging

    • George L. Sutphin, Brady A. Olsen, Brian K. Kennedy, Matt Kaeberlein
    Pages 251-289

  14. Genetic Approaches to Aging in Budding and Fission Yeasts: New Connections and New Opportunities

    • Bo-Ruei Chen, Kurt W. Runge
    Pages 291-314

  15. Evolution of Asymmetric Damage Segregation : A Modelling Approach

    • Armin Rashidi, Thomas B.L. Kirkwood, Daryl P. Shanley
    Pages 315-330

  16. Cellular Ageing and the Actin Cytoskeleton

    • David Amberg, Jane E. Leadsham, Vasillios Kotiadis, Campbell W. Gourlay
    Pages 331-352

  17. Back Matter

    Pages 353-365
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Keywords

About this book

This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.

Reviews

From the reviews:

“This book compiles some of the most exciting and promising research to date in the fields of anti-aging, longevity, and possibly even rejuvenation. The authors’ research examines the role of senescence in yeast and how it may relate to the chaotic autophagy of cancer cells. In sum, Aging Research will stir interest in both scientific and non-scientific arenas.” (The Electric Review, October, 2012)

Editors and Affiliations

  • , Department of Cell Biology, University of Salzburg, Salzburg, Austria

    Michael Breitenbach, Peter Laun

  • , Tulane Center for Aging and Department o, Tulane University Health Sciences Center, New Orleans, USA

    S. Michal Jazwinski

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