Subcellular Biochemistry

Aging Research in Yeast

Editors: Breitenbach, Michael, Jazwinski, S. Michal, Laun, Peter (Eds.)

  • Yeast aging research and its relevance to humans
  • Thorough account of a rapidly expanding field
  • Offers a molecular cell biology perspective on aging
  • Written by authorities in the field of aging research
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eBook $199.00
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  • ISBN 978-94-007-2561-4
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Hardcover $259.00
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  • ISBN 978-94-007-2560-7
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Softcover $259.00
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  • ISBN 978-94-007-9420-7
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About this book

This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.

Reviews

From the reviews:

“This book compiles some of the most exciting and promising research to date in the fields of anti-aging, longevity, and possibly even rejuvenation. The authors’ research examines the role of senescence in yeast and how it may relate to the chaotic autophagy of cancer cells. In sum, Aging Research will stir interest in both scientific and non-scientific arenas.” (The Electric Review, October, 2012)

Table of contents (15 chapters)

  • Introduction

    Breitenbach, Michael (et al.)

    Pages 1-12

  • Oxidative Stresses and Ageing

    Aung-Htut, May T. (et al.)

    Pages 13-54

  • The Role of Mitochondria in the Aging Processes of Yeast

    Breitenbach, Michael (et al.)

    Pages 55-78

  • The Retrograde ResponseRetrograde Response and Other Pathways of Interorganelle CommunicationInterorganelle Communication in Yeast Replicative Aging

    Jazwinski, S. Michal

    Pages 79-100

  • Chronological Aging in Saccharomyces cerevisiae

    Longo, Valter D. (et al.)

    Pages 101-121

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-94-007-2561-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-94-007-2560-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-94-007-9420-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Aging Research in Yeast
Editors
  • Michael Breitenbach
  • S. Michal Jazwinski
  • Peter Laun
Series Title
Subcellular Biochemistry
Series Volume
57
Copyright
2012
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-94-007-2561-4
DOI
10.1007/978-94-007-2561-4
Hardcover ISBN
978-94-007-2560-7
Softcover ISBN
978-94-007-9420-7
Series ISSN
0306-0225
Edition Number
1
Number of Pages
XII, 368
Topics