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Lactoferrin and its Role in Wound Healing

Authors: Takayama, Yoshiharu

  • Provides the recent advances in molecular mechanisms of wound healing
  • Provides in-depth information on roles of lactoferrin as a signaling molecule
  • Presents the scientific background on use of lactoferrin as a wound healing agent
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eBook $119.00
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  • ISBN 978-94-007-2467-9
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Hardcover $159.00
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  • ISBN 978-94-007-2466-2
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Softcover $159.00
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  • ISBN 978-94-007-9202-9
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About this book

Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Protein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway. In addition, lactoferrin promotes biosynthesis of extracellular matrix (ECM) component such as type-I collagen and hyaluronan. Hyaluronan is a major component of ECM in connective tissue and promotes wound healing. The promoting effect of lactoferrin on hyaluronan production was accompanied by promotion of HAS2 (hyaluronan synthase 2) expression. These observations suggest that lactoferrin promotes the wound healing by providing an ECM that promotes fibroblast migration. Lactoferrin is also known for its anti-inflammatory and immune modulating properties. According to recent in vivo study, lactoferrin promotes wound repair by promoting the early inflammatory phase of wound healing. Based on this, recombinant human lactoferrin was subsequently tested clinically in a Phase II trial in patients with diabetic ulcers and was found to be effective. Lactoferrin should be further evaluated in patients with diabetic and other types of ulcers.

Table of contents (5 chapters)

  • Molecular Regulation of Skin Wound Healing

    Takayama, Yoshiharu

    Pages 1-23

  • Role of Hyaluronan in Wound Healing

    Takayama, Yoshiharu

    Pages 25-42

  • Lactoferrin Structure Function and Genetics

    Takayama, Yoshiharu

    Pages 43-66

  • Lactoferrin as a Signaling Mediator

    Takayama, Yoshiharu

    Pages 67-85

  • Effects of Lactoferrin on Skin Wound Healing

    Takayama, Yoshiharu

    Pages 87-100

Buy this book

eBook $119.00
price for USA (gross)
  • ISBN 978-94-007-2467-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $159.00
price for USA
  • ISBN 978-94-007-2466-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.00
price for USA
  • ISBN 978-94-007-9202-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Lactoferrin and its Role in Wound Healing
Authors
Copyright
2012
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-94-007-2467-9
DOI
10.1007/978-94-007-2467-9
Hardcover ISBN
978-94-007-2466-2
Softcover ISBN
978-94-007-9202-9
Edition Number
1
Number of Pages
XII, 108
Topics