Tumors of the Central Nervous System

Tumors of the Central Nervous System, Volume 5

Astrocytomas, Hemangioblastomas, and Gangliogliomas

Editors: Hayat, M.A. (Ed.)

  • Diagnosis of brain tumors, including imaging techniques
  • Therapy for brain tumors and its effectiveness
  • Biomarkers for brain tumors
  • Molecular genetics of brain tumors
  • Genetics of epilepsy
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eBook $199.00
price for USA (gross)
  • ISBN 978-94-007-2019-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-94-007-2018-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-94-007-3826-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented.  The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme.

The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented.  The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme.

Reviews

From the reviews:

“This book covers the molecular, medical, radiosurgical, and surgical management of intracranial tumors including astrocytomas, hemangioblastomas, and gangliogliomas. The purpose is to address the most recent advances in the management of these tumors. Neurologists, neurosurgeons, and radiologists are the intended audience. … This is an excellent contribution to neurosurgery and should be part of most academic neurosurgery and neurology libraries.” (Celso Agner, Doody’s Review Service, April, 2012)


Table of contents (30 chapters)

  • Methylation in Malignant Astrocytomas

    Inda, María del Mar (et al.)

    Pages 3-12

  • Deciphering the Function of Doppel Protein in Astrocytomas

    Azzalin, Alberto (et al.)

    Pages 13-22

  • Astrocytic Tumors: Role of Antiapoptotic Proteins

    Conti, Alfredo (et al.)

    Pages 23-33

  • Deregulation of the Wnt/β-Catenin/Tcf Signaling Pathway in Astrocytomas

    Sareddy, Gangadhara Reddy (et al.)

    Pages 35-44

  • Subependymal Giant Cell Astrocytoma: Role of mTOR Pathway and Its Inhibitors

    Kotulska, Katarzyna (et al.)

    Pages 45-55

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-94-007-2019-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
  • ISBN 978-94-007-2018-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-94-007-3826-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Tumors of the Central Nervous System, Volume 5
Book Subtitle
Astrocytomas, Hemangioblastomas, and Gangliogliomas
Editors
  • M.A. Hayat
Series Title
Tumors of the Central Nervous System
Series Volume
5
Copyright
2012
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-94-007-2019-0
DOI
10.1007/978-94-007-2019-0
Hardcover ISBN
978-94-007-2018-3
Softcover ISBN
978-94-007-3826-3
Series ISSN
2215-096X
Edition Number
1
Number of Pages
XXVI, 290
Topics