Editors:
- Comprehensive set of reviews dealing with mechanisms of uptake by cells and tissues
- Covering several key chemical areas of preparation of nanovehicles
- Delivers some important application areas in medicine
- Written by world experts in this field
- Includes supplementary material: sn.pub/extras
Part of the book series: Fundamental Biomedical Technologies (FBMT, volume 5)
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Table of contents (26 chapters)
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Front Matter
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Mechanisms of Uptake and Targeting
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Front Matter
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Mechanisms of uptake and targeting
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Nanocarrier Formulation
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Front Matter
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Nanocarrier formulation
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Medical Applications
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Front Matter
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About this book
This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices.
This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included.
Intracellular delivery / therapy is a highlytopical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.
Editors and Affiliations
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, Chemical and Biological Engineering, Vanderbilt University, Nashville, USA
Aleš Prokop
Bibliographic Information
Book Title: Intracellular Delivery
Book Subtitle: Fundamentals and Applications
Editors: Aleš Prokop
Series Title: Fundamental Biomedical Technologies
DOI: https://doi.org/10.1007/978-94-007-1248-5
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2011
Hardcover ISBN: 978-94-007-1247-8Published: 27 May 2011
eBook ISBN: 978-94-007-1248-5Published: 26 May 2011
Series ISSN: 1559-7083
Series E-ISSN: 2626-8655
Edition Number: 1
Number of Pages: XIX, 867
Number of Illustrations: 186 b/w illustrations, 95 illustrations in colour
Topics: Cell Biology