Subcellular Biochemistry

Purinergic Regulation of Respiratory Diseases

Editors: Picher, Maryse, Boucher, Richard C. (Eds.)

  • Pivotal Roles of Purinergic Signaling in Airway Defenses
  • Disease-Specific Aberrances in Sputum Adenosine Regulation
  • Diagnostic Value of AMP-Mediated Bronchoconstriction
  • Distinct Therapies for Acute Lung Injury and Chronic Lung Diseases
  • Critical Analysis of Past and Current Clinical Trials
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About this book

We proudly present the first book to integrate all aspects of purinergic signaling in the respiratory system. The first chapters introduce basic notions of purinergic pharmacology and metabolism, which allows readers from all scientific backgrounds to fully grasp the importance of these signaling networks for airway defenses, including mucociliary clearance and inflammatory responses. Then, chapters are devoted to the groundbreaking discovery that chronic respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD), present specific aberrances in purinergic signaling which essentially drive lung complications. The last chapters describe the animal models used to investigate purinergic signaling in respiratory diseases, and the therapeutic applications developed by the pharmaceutical industry based on receptor agonists/antagonists and metabolic correctors. This highly comprehensive manuscript constitutes an invaluable tool for beginners and experts to follow the rapidly evolving research field of purinergic signaling. Furthermore, the critical analysis of past clinical protocols should facilitate the identification of potent therapeutic targets, and provide a better understanding of the data acquired in current clinical trials.

Table of contents (9 chapters)

  • Nucleotide Release by Airway Epithelia

    Lazarowski, Eduardo R. (et al.)

    Pages 1-15

  • Mechanisms Regulating Airway Nucleotides

    Picher, Maryse

    Pages 17-49

  • Computational Model for the Regulation of Extracellular ATP and Adenosine in Airway Epithelia

    Garcia, Guilherme J. M. (et al.)

    Pages 51-74

  • Regulation of Airway Nucleotides in Chronic Lung Diseases

    Esther, Charles R. (et al.)

    Pages 75-93

  • Nucleotide-Mediated Airway Clearance

    Schmid, Andreas (et al.)

    Pages 95-138

Buy this book

eBook n/a
  • ISBN 978-94-007-1217-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-94-007-1216-4
  • Free shipping for individuals worldwide
Softcover n/a
  • ISBN 978-94-007-3606-1
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Purinergic Regulation of Respiratory Diseases
Editors
  • Maryse Picher
  • Richard C. Boucher
Series Title
Subcellular Biochemistry
Series Volume
55
Copyright
2011
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-94-007-1217-1
DOI
10.1007/978-94-007-1217-1
Hardcover ISBN
978-94-007-1216-4
Softcover ISBN
978-94-007-3606-1
Series ISSN
0306-0225
Edition Number
1
Number of Pages
XVIII, 282
Topics