Tumor-Associated Fibroblasts and their Matrix

1. Front Matter

   Pages 1-1

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2. The Tumor Microenvironment

   1. Front Matter

      Pages 1-1

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   2. Critical Roles of Stromal Fibroblasts in the Cancer Microenvironments

      • Leland W. K. Chung

      Pages 3-19

3. Stromal Cell Diversity

   1. Front Matter

      Pages 21-21

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   2. Functional Diversity of Fibroblasts

      • H. Peter Rodemann, Hans-Oliver Rennekampff

      Pages 23-36

   3. The Role of the Myofibroblast in Fibrosis and Cancer Progression

      • Boris Hinz, Ian A. Darby, Giulio Gabbiani, Alexis Desmoulière

      Pages 37-74

   4. The Role of Myofibroblasts in Communicating Tumor Ecosystems

      • Olivier De Wever, Astrid De Boeck, Pieter Demetter, Marc Mareel, Marc Bracke

      Pages 75-89

   5. Tumor Vessel Associated-Pericytes

      • Arne Bartol, Anna M. Laib, Hellmut G. Augustin

      Pages 91-110

   6. The Role of Cancer-Associated Adipocytes (CAA) in the Dynamic Interaction Between the Tumor and the Host

      • Marie-Christine Rio

      Pages 111-123

4. The Tumor ECM

   1. Front Matter

      Pages 125-125

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   2. Hyaluronan : A Key Microenvironmental Mediator of Tumor-Stromal Cell Interactions

      • Naoki Itano

      Pages 127-144

   3. Function of Tenascins in the Tumor Stroma

      • Florence Brellier, Ruth Chiquet-Ehrismann

      Pages 145-158

   4. Fibulins and Their Role in the ECM

      • Helen C. M. Cooney, William M. Gallagher

      Pages 159-174

   5. Tumor Fibroblast-Associated Metalloproteases

      • Julie Lecomte, Anne Masset, Dylan R. Edwards, Agnès Noël

      Pages 175-193

5. Tumor Modulating-Fibroblast Interactions

   1. Front Matter

      Pages 195-195

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   2. Multiple Fibroblast Phenotypes in Cancer Patients: Heterogeneity in Expression of Migration Stimulating Factor

      • Ana M. Schor, Seth L. Schor

      Pages 197-222

   3. TGF-β Signaling in Fibroblasts Regulates Tumor Initiation and Progression in Adjacent Epithelia

      • Brian R. Bierie, Harold L. Moses

      Pages 223-243

   4. The SDF-1 -Rich Tumour Microenvironment Provides a Niche for Carcinoma Cells

      • Masayuki Shimoda, Kieran Mellody, Akira Orimo

      Pages 245-255

   5. Role of PDGF in Tumor-Stroma Interactions

      • Carina Hellberg, Carl-Henrik Heldin

      Pages 257-265

   6. Radiation-Induced Microenvironments and Their Role in Carcinogenesis

      • Mary Helen Barcellos-Hoff, David H. Nguyen

      Pages 267-282

During the last 20 years it has become increasingly clear that the tumor micro-environment, the tumor stroma with its cellular end extracellular components, plays an crucial role in regulating tumor growth and progression. This book on “Tumor-associated fibroblasts and their matrix” as part of the series on “Tumor-Microenvironment” is the first comprehensive discussion of these two main players of the tumor microenvironment. The best experts in this new area of tumor research and therapy review the role of these major components in the tumor stroma in the process of tumor development and progression. They discuss their interaction with other players such as blood vessels and immune cells, and show novel perspectives for tumor therapy. This compilation of excellent contributions of the best known experts in this important field in cancer research and therapy is a must for all scientists engaged in basic and clinical research. Increasing evidence of successful targeting of both cellular and matrix components in tumor therapy renders this book of particular interest for scientists engaged in pharmaceutical industry searching for new components for cancer therapy.

• cancer associated fibroblasts
• novel targets for tumor therapy
• tumor microenvironment
• tumor specific ECM
• tumor-stroma interactions

• Villingen-Schwenningen, Germany

  Margareta M. Mueller

• Heidelberg, Germany

  Norbert E. Fusenig

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