Cancer Metastasis - Biology and Treatment

Liver Metastasis: Biology and Clinical Management

Editors: Brodt, Pnina (Ed.)

  • Comprehensive and timely reviews on different aspects of the biology of liver metastasis
  • A unique combination of chapters on basic biological mechanisms and clinical aspects of liver metastasis
  • Written by experts in the respective fields
  • Unlike other books now available on this subject, this book does not restrict its focus to colon or GI cancers
  • Will appeal to clinicians and laboratory scientists as well as trainees in both disciplines
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eBook $219.00
price for USA (gross)
  • ISBN 978-94-007-0292-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-94-007-0291-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA
  • ISBN 978-94-007-3545-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. 

 

Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails.   Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. 

 

Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities.

 

By combining information on biological and clinical aspects of liver metastasis, this volume  will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.

Table of contents (16 chapters)

  • Introduction

    Brodt, Pnina

    Pages 1-5

  • Architectural and Functional Aspects of the Liver with Implications for Cancer Metastasis

    Vidal-Vanaclocha, Fernando

    Pages 9-42

  • The Tumor Microenvironment at Different Stages of Hepatic Metastasis

    Vidal-Vanaclocha, Fernando

    Pages 43-87

  • The Colorectal Cancer Initiating Cell: Markers and Their Role in Liver Metastasis

    Zöller, Margot (et al.)

    Pages 89-127

  • Role of CXC Chemokines and Receptors in Liver Metastasis – Impact on Liver Resection-Induced Engraftment and Tumor Growth

    Kollmar, Otto (et al.)

    Pages 129-154

Buy this book

eBook $219.00
price for USA (gross)
  • ISBN 978-94-007-0292-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.00
price for USA
  • ISBN 978-94-007-0291-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $279.00
price for USA
  • ISBN 978-94-007-3545-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Liver Metastasis: Biology and Clinical Management
Editors
  • Pnina Brodt
Series Title
Cancer Metastasis - Biology and Treatment
Series Volume
16
Copyright
2011
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-94-007-0292-9
DOI
10.1007/978-94-007-0292-9
Hardcover ISBN
978-94-007-0291-2
Softcover ISBN
978-94-007-3545-3
Series ISSN
1568-2102
Edition Number
1
Number of Pages
XIV, 446
Topics