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Mechanosensitivity in Cells and Tissues

Mechanosensitivity and Mechanotransduction

Editors: Kamkin, Andre, Kiseleva, Irina (Eds.)

  • One book provides a detailed description of molecular mechanisms of mechanosensing and mechanotransduction in different cells
  • One book brings together a comprehensive outline of modern vision of structure and functions of cytoskeleton
  • Provides a wide and detailed description of various signaling pathways
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eBook $199.00
price for USA (gross)
  • ISBN 978-90-481-9881-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
valid through October 16, 2017
  • ISBN 978-90-481-9880-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-94-007-3432-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book presents the latest findings in the field of research of mechanosensitivity and
mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction
of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It  contains a detailed description of several  stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of  nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii  cations via intracellular cytoskeletal reorganization and
extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume  highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes.

This book is a unique collection of reviews outlining current knowledge and future developments
in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of
studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. 

This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Table of contents (15 chapters)

  • Integrin-Mediated Mechanotransduction in Vascular Smooth Muscle Cells

    Yip, Kay-Pong (et al.)

    Pages 3-24

  • The Role of the Actin Cytoskeleton in Mechanosensation

    Luo, Tianzhi (et al.)

    Pages 25-65

  • Effect of Cytoskeleton on the Mechanosensitivity of Genes in Osteoblasts

    Fu, Qiang (et al.)

    Pages 67-76

  • Involvement of the Cytoskeletal Elements in Articular Cartilage Mechanotransduction

    Blain, Emma J.

    Pages 77-106

  • The Role of Nitric Oxide in the Regulation of Mechanically Gated Channels in the Heart

    Kazanski, Victor (et al.)

    Pages 109-140

Buy this book

eBook $199.00
price for USA (gross)
  • ISBN 978-90-481-9881-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $259.00
price for USA
valid through October 16, 2017
  • ISBN 978-90-481-9880-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $259.00
price for USA
  • ISBN 978-94-007-3432-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mechanosensitivity and Mechanotransduction
Editors
  • Andre Kamkin
  • Irina Kiseleva
Series Title
Mechanosensitivity in Cells and Tissues
Series Volume
4
Copyright
2011
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-90-481-9881-8
DOI
10.1007/978-90-481-9881-8
Hardcover ISBN
978-90-481-9880-1
Softcover ISBN
978-94-007-3432-6
Edition Number
1
Number of Pages
XXIV, 371
Topics