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Mechanosensitivity and Mechanotransduction

  • Book
  • © 2011

Overview

Editors:
  1. Andre Kamkin

    1. Chemical Department, Moscow State University, Moscow, Russian Federation

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    You can also search for this editor in PubMed   Google Scholar

  2. Irina Kiseleva

    1. , Department of Fundamental and Applied Ph, Russian State Medical University, Moscow, Russian Federation

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • One book provides a detailed description of molecular mechanisms of mechanosensing and mechanotransduction in different cells
  • One book brings together a comprehensive outline of modern vision of structure and functions of cytoskeleton
  • Gives a wide and detailed coverage of mechanosensitive ion channels
  • Provides a wide and detailed description of various signaling pathways

Part of the book series: Mechanosensitivity in Cells and Tissues (MECT, volume 4)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xxiv
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  2. The Role of Cytoskeleton in Mechanosensitivity and Mechanotransduction

    1. Front Matter

      Pages 1-1
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    2. Integrin-Mediated Mechanotransduction in Vascular Smooth Muscle Cells

      • Kay-Pong Yip, Lavanya Balasubramanian, James S. K. Sham
      Pages 3-24

    3. The Role of the Actin Cytoskeleton in Mechanosensation

      • Tianzhi Luo, Douglas N. Robinson
      Pages 25-65

    4. Effect of Cytoskeleton on the Mechanosensitivity of Genes in Osteoblasts

      • Qiang Fu, Yiping Zhang, Yajuan Xu, Yourui Li, Ling Guo, Minfeng Shao
      Pages 67-76

    5. Involvement of the Cytoskeletal Elements in Articular Cartilage Mechanotransduction

      • Emma J. Blain
      Pages 77-106

  3. Molecular Mechanisms of Mechanotransduction and Ion Channels Modulation

    1. Front Matter

      Pages 107-107
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    2. The Role of Nitric Oxide in the Regulation of Mechanically Gated Channels in the Heart

      • Victor Kazanski, Andre Kamkin, Ekaterina Makarenko, Natalia Lysenko, Natalia Lapina, Irina Kiseleva
      Pages 109-140

    3. Role of Signaling Pathways in the Myocardial Response to Biomechanical Stress and in Mechanotransduction in the Heart

      • Danny Guo, Zamaneh Kassiri, Gavin Y. Oudit
      Pages 141-166

    4. Atomistic Molecular Simulation of Gating Modifier Venom Peptides – Two Binding Modes and Effects of Lipid Structure

      • Kazuhisa Nishizawa
      Pages 167-190

  4. Mechanosensitivity and Mechanotransduction in Vascular Cells

    1. Front Matter

      Pages 191-191
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    2. Cellular and Molecular Effects of Mechanical Stretch on Vascular Cells

      • Kou-Gi Shyu
      Pages 193-217

    3. Role of Proteoglycans in Vascular Mechanotransduction

      • Aaron B. Baker
      Pages 219-236

  5. Mechanotransduction in the Lung

    1. Front Matter

      Pages 237-237
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    2. Control of TRPV4 and Its Effect on the Lung

      • James C. Parker, Mary I. Townsley
      Pages 239-254

    3. The Role of Protein-protein Interactions in Mechanotransduction: Implications in Ventilator Induced Lung Injury

      • Matthew Rubacha, Mingyao Liu
      Pages 255-273

  6. Mechanosensing and Mechanotransduction in Bone and Joint Tissues

    1. Front Matter

      Pages 275-275
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    2. Cellular Mechanisms of Mechanotransduction in Bone

      • Suzanne R.L. Young, Fredrick M. Pavalko
      Pages 277-296

    3. The Mechanosensitivity of Cells in Joint Tissues: Role in the Pathogenesis of Joint Diseases

      • Christelle Sanchez, Marianne Mathy-Hartert, Yves Henrotin
      Pages 297-313

  7. Mechanotransduction of Sensor System

    1. Front Matter

      Pages 315-315
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Keywords

About this book

This book presents the latest findings in the field of research of mechanosensitivity and
mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction
of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It  contains a detailed description of several  stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of  nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii  cations via intracellular cytoskeletal reorganization and
extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume  highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes.

This book is a unique collection of reviews outlining current knowledge and future developments
in this rapidly growing field. Currently, investigations of the molecular mechanisms ofmechanosensitivity and mechanotransduction are focused on several issues. The majority of
studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. 

This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Editors and Affiliations

  • Chemical Department, Moscow State University, Moscow, Russian Federation

    Andre Kamkin

  • , Department of Fundamental and Applied Ph, Russian State Medical University, Moscow, Russian Federation

    Irina Kiseleva

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