Cancer Metastasis - Biology and Treatment

Signal Transduction in Cancer Metastasis

Editors: Wu, Wen-Sheng, Hu, Chi-Tan (Eds.)

  • Offers comprehensive reviews of signal transduction triggering tumor metastasis
  • Examines the novel mechanisms for how cross talks of different signal pathways achieve
  • Details encouraging potential clinical applications for prevention of tumor metastasis
see more benefits

Buy this book

eBook $179.00
price for USA (gross)
  • ISBN 978-90-481-9522-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
  • ISBN 978-90-481-9521-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $229.00
price for USA
  • ISBN 978-94-007-3358-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blokcade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study.

Table of contents (14 chapters)

  • Overview of Signal Transduction in Tumor Metastasis

    Wu, Wen-Sheng (et al.)

    Pages 1-8

  • Microenvironment Triggers EMT, Migration and Invasion of Primary Tumor via Multiple Signal Pathways

    Wu, Wen-Sheng (et al.)

    Pages 9-24

  • The ERK1/2 MAP Kinase Signaling Pathway in Tumor Progression and Metastasis

    Voisin∗, Laure (et al.)

    Pages 25-40

  • Mitogen-Activated Protein Kinase-Activated Protein Kinases and Metastasis

    Shiryaev, Alexey (et al.)

    Pages 41-76

  • Grb2 and Other Adaptor Proteins in Tumor Metastasis

    Giubellino, Alessio (et al.)

    Pages 77-102

Buy this book

eBook $179.00
price for USA (gross)
  • ISBN 978-90-481-9522-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $229.00
price for USA
  • ISBN 978-90-481-9521-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $229.00
price for USA
  • ISBN 978-94-007-3358-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Signal Transduction in Cancer Metastasis
Editors
  • Wen-Sheng Wu
  • Chi-Tan Hu
Series Title
Cancer Metastasis - Biology and Treatment
Series Volume
15
Copyright
2010
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-90-481-9522-0
DOI
10.1007/978-90-481-9522-0
Hardcover ISBN
978-90-481-9521-3
Softcover ISBN
978-94-007-3358-9
Series ISSN
1568-2102
Edition Number
1
Number of Pages
XII, 288
Topics