Subcellular Biochemistry

Endotoxins: Structure, Function and Recognition

Editors: Wang, Xiaoyuan, Quinn, Peter J. (Eds.)

  • Gives new insights into the role of the innate immune system in infection by gram-negative bacteria
  • Presents a description of endotoxins according to their biosynthesis, genetic constitution, structure, function and mode of interaction with host cells
  • Brings together contributions from researchers in the forefront of endotoxin research
  • Provides fundamental understanding of the mechanism behind whole-body inflammation or sepsis.
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eBook $229.00
price for USA (gross)
  • ISBN 978-90-481-9078-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-90-481-9077-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-94-007-3267-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.

Reviews

From the reviews:

“The book consists of two parts that include 17 chapters prepared by an international team of well_ known experts. … The book is well prepared. There are many good quality photos, graphs, and pictures. Each chapter ends with a base reference, and there is a subject index at the end of the book. … very useful for many researchers in the field of biochemistry, biotechnology, immunology, and medicinal chemistry. This book can also be a useful tool for teachers and students of colleges and universities.” (G. Ya. Wiederschain, Biochemistry, Vol. 76 (5), May, 2011)

Table of contents (17 chapters)

  • Endotoxins: Lipopolysaccharides of Gram-Negative Bacteria

    Wang, Xiaoyuan (et al.)

    Pages 3-25

  • Purification and Characterization of Lipopolysaccharides

    Wang, Xiaoyuan (et al.)

    Pages 27-51

  • Endotoxins: Relationship Between Structure, Function, and Activity

    Brandenburg, K. (et al.)

    Pages 53-67

  • The Diversity of the Core Oligosaccharide in Lipopolysaccharides

    Silipo, Alba (et al.)

    Pages 69-99

  • Salmonella-Regulated Lipopolysaccharide Modifications

    Richards, Susan M. (et al.)

    Pages 101-122

Buy this book

eBook $229.00
price for USA (gross)
  • ISBN 978-90-481-9078-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-90-481-9077-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $289.00
price for USA
valid through November 5, 2017
  • ISBN 978-94-007-3267-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Endotoxins: Structure, Function and Recognition
Editors
  • Xiaoyuan Wang
  • Peter J. Quinn
Series Title
Subcellular Biochemistry
Series Volume
53
Copyright
2010
Publisher
Springer Netherlands
Copyright Holder
Springer Science+Business Media B.V.
eBook ISBN
978-90-481-9078-2
DOI
10.1007/978-90-481-9078-2
Hardcover ISBN
978-90-481-9077-5
Softcover ISBN
978-94-007-3267-4
Series ISSN
0306-0225
Edition Number
1
Number of Pages
XVII, 415
Topics