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Magnetic Resonance Techniques in Clinical Trials in Multiple Sclerosis

  • Conference proceedings
  • © 1999

Overview

Editors:
  1. Massimo Filippi

    1. Neuroimaging Research Unit, Department of Neuroscience Scientific Institute Ospedale San Raffaele, University of Milan, Italy

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  2. Robert I. Grossman

    1. Department of Radiology, University of Pennsylvania, USA

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  3. Giancarlo Comi

    1. Clinical Trials Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Topics in Neuroscience (TOPNEURO)

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Table of contents (11 papers)

  1. Front Matter

    Pages I-XI
    Download chapter PDF

  2. Introduction

    • M. Filippi, R. I. Grossman, G. Comi
    Pages 1-2

  3. Clinical and Paraclinical Outcomes for Treatment Trials in Multiple Sclerosis

    • G. Comi, M. Rovaris
    Pages 3-20

  4. The Use of Magnetic Resonance Imaging to Select Patients for Multiple Sclerosis Clinical Trials

    • J. H. Simon
    Pages 21-36

  5. The Application of Magnetic Resonance Imaging to Phase II Trials in Multiple Sclerosis

    • H. F. McFarland, J. A. Frank
    Pages 37-48

  6. Magnetic Resonance Imaging Techniques to Monitor Phase III Treatment Trials

    • P. D. Molyneux, D. H. Miller
    Pages 49-73

  7. New Strategies to Increase Magnetic Resonance Imaging Sensitivity in Detecting Individual Multiple Sclerosis Lesions and Short-term Disease Activity: Perspectives for Future Clinical Trials

    • M. Filippi
    Pages 74-84

  8. Problems with Conventional Magnetic Resonance Imaging and New Strategies to Improve the Utility of MRI in Future Clinical Trials

    • R. I. Grossman
    Pages 85-105

  9. Review of the Results of Previous Phase II, Magnetic Resonance Imaging-monitored Clinical Trials

    • P. Soelberg Sørensen
    Pages 106-133

  10. Magnetic Resonance Imaging Techniques in Phase III Clinical Trials in Multiple Sclerosis

    • D. W. Paty, D. K. B. Li
    Pages 134-144

  11. Standardisation, Optimisation and Organisation of Magnetic Resonance Imaging for Monitoring Clinical Trials

    • M. A. Horsfield
    Pages 145-167

  12. Statistical Approaches to the Use of Magnetic Resonance Imaging Data for Clinical Trials

    • P. Bruzzi, M. P. Sormani
    Pages 168-185

  13. Back Matter

    Pages 187-192
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Keywords

About this book

We have entered an exciting period in the study of multiple sclerosis and its treatment. Central to this progress has been the introduction of magnetic reso­ nance techniques. When Young and his colleagues published the first images of the brain in multiple sclerosis at the end of 1981, it was at once obvious that magnetic resonance imaging would playa major role in diagnosis. Intuitively one felt that it would also have a role in increasing our understanding of the pathogenesis of the disease and in monitoring treatment. And so it has proved. Important problems however remain, perhaps the most important of which at present is the weak predictive power of standard magnetic resonance ima­ ging methods in determining the possibility of progression of impairment and disability. Recently, there have been advances which promise to overcome some of these problems, but decisions about what approach to adopt in selecting patients for clinical trials and which techniques to use in monitoring treatment during their course are still difficult. In this book, Dr. Filippi and his colleagues have assembled an outstanding group of contributors whose work is central to the progress that is being made. The coverage of the issues involved in the use of magnetic resonance techniques in assessing therapeutic effect is comprehensive and, though the field is chan­ ging rapidly, the principles and much of the detail in the book are likely to have lasting value.

Editors and Affiliations

  • Neuroimaging Research Unit, Department of Neuroscience Scientific Institute Ospedale San Raffaele, University of Milan, Italy

    Massimo Filippi

  • Department of Radiology, University of Pennsylvania, USA

    Robert I. Grossman

  • Clinical Trials Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy

    Giancarlo Comi

Bibliographic Information

  • Book Title: Magnetic Resonance Techniques in Clinical Trials in Multiple Sclerosis

  • Editors: Massimo Filippi, Robert I. Grossman, Giancarlo Comi

  • Series Title: Topics in Neuroscience

  • DOI: https://doi.org/10.1007/978-88-470-2153-2

  • Publisher: Springer Milano

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Italia 1999

  • Hardcover ISBN: 978-88-470-0041-4Published: 01 December 1998

  • Softcover ISBN: 978-88-470-2180-8Published: 05 November 2012

  • eBook ISBN: 978-88-470-2153-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 192

  • Topics: Neuroradiology, Neurology

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