Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach

Editors: De Ponte, Francesco Saverio (Ed.)

  • First multidisciplinary text on the subject, by worldwide experts
  • Update of the latest advances, technical details, and expert advice regarding this subject
  • Presents multiple designs, explanatory figures on physiopathogenesis, and clinical imaging
  • Clinical case discussions and practical advice for incorporation into common practice
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About this book

During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn't until 2003 that today's intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic bone of the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of these drugs, which are commonly used for treating breast cancer or myeloma. In about 5% of cases, subjects with BIONJ were being treated for osteoporosis. Precipitating events that contribute to BIONJ are tooth extractions (about 50% of cases), mandibular exostoses, periodontal disease, and local trauma from ill-fitting dentures. It is not known if the placement of dental implants is a precipitating factor. The book aims to meet the need of medical practitioners working in all fields that use bisphosphonates, and to present the conservative and surgical treatment methods currently in use. There will also be detailed information on the literature relating to dental implants in patients treated with bisphosphonates.

Table of contents (15 chapters)

  • Introduction

    Marx, Robert E.

    Pages 1-11

  • Pharmacology: Mechanism of Action of Bisphosphonates

    Sarro, Angelina (et al.)

    Pages 13-22

  • Use of Bisphosphonates in Oncology

    Altavilla, Giuseppe (et al.)

    Pages 23-34

  • Use of Bisphosphonates in Hematology

    Musolino, Caterina (et al.)

    Pages 35-48

  • Use of Bisphosphonates in Osteoporosis

    Sarro, Angelina (et al.)

    Pages 49-57

Buy this book

eBook $109.00
price for USA (gross)
  • ISBN 978-88-470-2083-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.00
price for USA
  • ISBN 978-88-470-2082-5
  • Free shipping for individuals worldwide
  • Online orders shipping within 2-3 days.
Rent the ebook  
  • Rental duration: 1 or 6 month
  • low-cost access
  • online reader with highlighting and note-making option
  • can be used across all devices
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Bibliographic Information

Bibliographic Information
Book Title
Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach
Editors
  • Francesco Saverio De Ponte
Copyright
2012
Publisher
Springer-Verlag Mailand
Copyright Holder
Springer-Verlag Italia
eBook ISBN
978-88-470-2083-2
DOI
10.1007/978-88-470-2083-2
Hardcover ISBN
978-88-470-2082-5
Edition Number
1
Number of Pages
XIII, 181
Topics